Machine learning models trained with experimental data for antimicrobial activity and hemolysis are shown to produce new non-hemolytic peptides active against multidrug-resistant bacteria.

Skin and Soft Tissue Infections (SSTI) resulting from cat bites most commonly occur due to Pasteurella infection. However, other pathogens such as Β-Hemolytic Streptococci

Hemolytic Haemophilus are rarely isolated in the clinical laboratory, as they do not grow on sheep or human blood-agar alone. On rabbit blood-agar they grow well and are hemolytic, but they grow less well and are not hemolytic on sheep blood-agar with added X and V factors. A survey was made to determine their incidence in pharyngitis. From 28 of 100 sore throats and from 57 of 100 normal throa...

W E HAVE OBSERVED three patients' who had developed severe hemolytic anemia following aortic valve replacement with a Starr-Edwards ball valve.2 3 The anemia has persisted from 3 to 6 months following operation. Hemolytic anemia following repair of ostium primum defect with a Teflon patch with a regurgitant jet through the mitral cleft has been described.4-7 Hemolytic anemia following insertion...

By ISRAEL DAVIDSOHN, DAVID HERMONI AND ELEANOR G. HANAWALT H EMOLYTIC ANEMIA was one of the first diseases of blood produced artificially and studied in animals. Much valuable information has been gathered in this way. However, some moot points remain which require elucidation. In this paper experiment-s will be described which add to elucidation of the nature of a hitherto not fully understood...

idiopathic acquired hemolytic atsemia, Group II, hemolytic atsemia followitsg irus pmseumomsia and Group III, chrotsic hemolytic atsemia with hemoglohitsuria and Raynaud’s phemsomena. A detailed accoumst. of the climsical aspects of tise three patients of Group III was published by Ferrimams, Dacie, Keele amid Fullerton2 who also made an amsalysis of msine similar cases reported in the literatu...

By Bm N S. Bin L AND IRvIN N. KUHN A FORM OF HEMOLYTIC ANEMIA characterized by thrombocytopenia and the presence of fragmented red cells in the peripheral blood has been called microangiopathic hemolytic anemia by Brain, Dacie and Hourihane.’ These workers showed that in this disease the amount of hemoglobinemia and the degree of erythrocyte fragmentation correlated closely with the severity of...

We characterized the expression of a putative toxin of Bacillus anthracis, a member of the cholesterol-dependent cytolysin (CDC) family, which includes listeriolysin O, perfringolysin O, and streptolysin O. We named this cytotoxin anthrolysin O (ALO). Although B. anthracis expresses minimal hemolytic activity in clinical settings, we show that Sterne strain 7702 expresses hemolytic activity whe...

By Bm N S. Bin L AND IRvIN N. KUHN A FORM OF HEMOLYTIC ANEMIA characterized by thrombocytopenia and the presence of fragmented red cells in the peripheral blood has been called microangiopathic hemolytic anemia by Brain, Dacie and Hourihane.’ These workers showed that in this disease the amount of hemoglobinemia and the degree of erythrocyte fragmentation correlated closely with the severity of...