Objective(s): This research aimed to test the impact of liver ischemia/reperfusion (IR) insult on the activity of antioxidant enzymes, functional enzymes, histological, and hemodynamic parameters of heart, as well as protective function of crocin on these variables in rats.    Materials and Methods: Thirty two rats were randomly assigned into 4 experimental groups (8 rats in each). I: sham-oper...

Background: Hepatic steatosis is commonly observed in patients with chronic hepatitis C (CHC). Many studies indicate a relationship between steatosis and fibrosis progression. The aim of this study was to analyze the prevalence of hepatic steatosis and related factors in Iranian CHC patients.   Methods: One hundred and fifteen consecutive patients with CHC were enrolled which were treat...

Congenital Hepatic Fibrosis (CHF) is a rare disease that affects both the liver and kidneys.  Congenital hepatic fibrosis (CHF) is an autosomal recessive inherited malformation defined pathologically by a variable degree of periportal fibrosis and irregularly shaped proliferating bile ducts. Affected individuals also have impaired renal function, usually caused, in children and teenagers, by an...

Background: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease (CLD). Omega-3 fatty acids and antioxidants co-supplementation have been considered as an alternative treatment in NAFLD. This trial will evaluate camelina sativa oil (CSO) effects as a rich source of omega-3 fatty acids and antioxidants on cardiometabolic risk factors, metabolic endotoxemia, liver en...

Background: Acetaminophen overdose can result in hepatic injury, mainly through oxidative stress. Objective: We investigated the protective effect of Cuminum cyminum (C. cyminum) seed powder after acetaminophen administration. Methods: Thirty male rats were divided into five groups (n=6): Control group, Acetaminophen (A) group, and Acetaminophen + C. cyminum 200, 400, 800 mg/kg (A+C) groups. Af...

Mol. Nutr. Food Res. 2023, 67, 202200158 DOI: 10.1002/mnfr.202200158 Hepatic encephalopathy (HE) is a neurotoxic disease with spectrum of neuropsychiatric abnormalities that develops as result hepatic dysfunction. Chitooligosaccharides (COS) an oligosaccharide possesses prominent biological activities including incalculable hepatoprotective and neuroprotective effects. Here, COS has been proved...

Filling defects are often observed on 99mTc sulfur colloid liver scans. Hot spots are much less frequently seen. Superior vena cava syndrome is the most frequent cause of this finding. In this report 3 patients with S.V.C and budd - Chiari syndrome with HOT SPOT on liver scan are presented. Mechanisms of scintigraphic patterns are reviewed.