The incorporation of different cyclodextrin (CD) excipients such as HPbeta-CD, beta-CD, gamma-CD or alpha-CD into polymer millirods for complexing beta-lapachone (beta-lap), a potent anti-cancer drug, significantly improved the drug release kinetics with various drug release patterns. However, such a complex system requires a mechanistically based model in order to provide a quantitative unders...

A topical o/w cream containing tretinoin microspheres was prepared. Gelatin microspheres of tretinoin were prepared using coacervation method. These microspheres contained about 50% w/w tretinoin. The particle size range of microspheres was between 90-150 m m. In vitro drug release from microspheres and a cream formulation was studied. It was shown that drug release from microspheres followed H...

Abstract Kristiansen and Murwanashyaka recently proved that Robinson arithmetic, Q, is interpretable in an elementary theory of full binary trees, T. We prove that, conversely, T Q by producing a formal interpretation concatenation QT + , thereby also establishing mutual interpretability with several well-known weak essentially undecidable theories numbers, strings, sets. introduce “hybrid” str...

Abstract This work reports the preparation, characterization, and a drug release study of mesoporous silica nanoparticles (MNPSiO 2 ) functionalized with folic acid (FA) loaded Cis-Pt as targeted system to kill glioblastoma cancer cells. The MNPSiO were synthesized by Stöber method using hexadecyltrimethylammonium bromide templating agent, which was finally removed calcination at 550°C. chemica...

The objective of the current study was to develop and optimize a novel lyophilized liposomal formulation anticancer agent carmustine, or bis-chloroethyl nitrosourea (BCNU) for prolonged release that could overcome dose-dependent side effects improve its bioavailability at site action. optimization done using 32 factorial design approach wherein soya phosphatidylcholine (SPC) cholesterol (CH) as...

vitamin e (α-tocopherol) is a natural antioxidant very useful for preventing the harmful effects of uv sun rays as skin aging and cancers. in this study, different mlv formulations were made using egg lecithin and varying molar ratios of α-tocopherol and/or cholesterol, and their encapsulation efficiencies were determined. the best liposomal product was incorporated into a carbomer 980 gel. the...

Cellulite was identified by the orange-peel appearance of skin surface that presents in 80-90% post-pubertal women. Caffeine and grape seed oil were known can be used as an anti-cellulite agent. Microemulsion systems are could enhance diffusion rate drugs through skin. This study conducted to develop a microemulsion gel containing caffeine determine effect caffeine's vitro profile. prepared usi...