The aim of treating hyperbilirubinemia is preventing the serum bilirubin to reach neurotoxic levels, which is done by phototherapy or blood transfusion. However, pharmacological treatments still remain vague. Therefore the effects of adding either clofibrate or phenobarbital on treatment outcomes was evaluated in icteric non-hemolitic newborns. Ninety neonates were divided in three groups. Two ...

Background: Jaundice is one of the most leading causes of neonate hospitalization (51.8%) during the first four weeks of life, and phototherapy is one of the most common and safest methods for the treatment of jaundice. Different results have been obtained from the studies conducted on the investigation of factors affecting increased phototherapy effect on the reduction of neonatal jaundice. Ho...

Dear Editor, Clofibrate is an activator of peroxisome proliferators-activated receptors (PPARS). This agent has been used for decreasing lipid levels in adults for years.1,2 It is also a glucuronyl transferase inducer which may increase bilirubin conjunction and excretion and not only has a therapeutic effect on hyperbilirubinemia in term neonates but also prevents hyperbilirubinemia in preterm...

introduction: one of the most common pathologies in neonates is hyperbilirubinemia, which is a good marker for damage to the central nervous system. the sensitivity of the auditory system to bilirubin has been previously documented, with much discrepancy in its effects on auditory brainstem response results. thus the objective of this study was to evaluate the effects of hyperbilirubinemia on a...

Jaundice occurs in most newborn infants. Most jaundice is benign, but because of the potential toxicity of bilirubin, newborn infants must be monitored to identify those who might develop severe hyperbilirubinemia and, in rare cases, acute bilirubin encephalopathy or kernicterus. The focus of this guideline is to reduce the incidence of severe hyperbilirubinemia and bilirubin encephalopathy whi...

BACKGROUND Weight loss of greater than 7% from birth weight indicates possible feeding problems. Inadequate oral intake causes weight loss and increases the bilirubin enterohepatic circulation. The objective of this study was to describe the association between total serum bilirubin (TSB) levels and weight loss in healthy term infants readmitted for hyperbilirubinemia after birth hospitalizatio...

        Infant jaundice is observed during the first week of life in approximately 60% of term and 80% of preterm infants. Hyperbilirubinemia may lead to the development of kernicterus, hearing loss, and convulsion. The goal of therapy in hyperbilirubinemia is lowering blood bilirubin levels or at least preventing its increase. It is recommended that phototherapy and if unsuccessful, blood exch...

Background: Hyperbilirubinemia is considered one of the most prevalent problems in newborns. Phototherapy, exchange transfusion, and herbal medicine are common therapeutic approaches for preventing any neurologic damage in infants with neonatal jaundice. However, herbal medicine is less commonly used. Aim: This study aimed to investigate the effect of bilineaster drop on neonatal hyperbilirubin...