BACKGROUND For more than 20 years in Italy, young athletes have been screened before participating in competitive sports. We assessed whether this strategy results in the prevention of sudden death from hypertrophic cardiomyopathy, a common cardiovascular cause of death in young athletes. METHODS We prospectively studied sudden deaths among athletes and nonathletes (35 years of age or less) i...

  Transient ischemic left ventricular dilation (TID) is a marker of severe and extensive coronary artery disease as well as an increased risk of adverse outcomes. The patients with more severe and extensive ischemia, multivessel-type of perfusion abnormality as well as patients with left anterior descending artery (LAD) territory perfusion abnormality have more probab...

Abstract Introduction In the last few years, genetic investigation has become an active part of diagnostic and therapeutic pathway cardiological patients with cardiomyopathies. Genetic assumes a key role in clinical–decision–making process proband acquiring potential changing clinical action. Patients referred for screening are affected by hypertrophic, arrhythmogenic dilated cardiomyopathy. fo...

Hypertrophic cardiomyopathy is a genetic cardiac disease with a particularly heterogeneous presentation and diverse natural history. Sudden and unexpected death has been recognized as a prominent and devastating consequence of hypertrophic cardiomyopathy since the initial description of this disease over 40 years ago. Many authors have emphasized that these catastrophic events occur not uncommo...

Citation: Monasky MM, Ciconte G, Anastasia L and Pappone C (2017) Commentary: Next Generation Sequencing and Linkage Analysis for the Molecular Diagnosis of a Novel Overlapping Syndrome Characterized by Hypertrophic Cardiomyopathy and Typical Electrical Instability of Brugada Syndrome. Front. Physiol. 8:1056. doi: 10.3389/fphys.2017.01056 Commentary: Next Generation Sequencing and Linkage Analy...

Two siblings from a family in which neurofibromatosis was inherited as an autosomal dominant had hypertrophic cardiomyopathy and neurofibromatosis. Idiopathic hypertrophic cardiomyopathy may have occurred by chance in two first degree relatives with neurofibromatosis. An alternative explantation is that these diseases are both manifestations of a common hereditary defect of neural crest tissue....

Hypertrophic cardiomyopathy is the most common monogenic disorder in cardiology. Despite important advances in understanding disease pathogenesis, it is not clear how flaws in individual sarcomere components are responsible for the observed phenotype. The aim of this article is to provide a brief interpretative analysis of some currently proposed pathophysiological mechanisms of hypertrophic ca...

We describe an uncommon association between Leopard syndrome and hypertrophic cardiomyopathy in a 27-year-old woman, who was little symptomatic and came for sudden death risk stratification and prevention. She has a rare syndrome, whose symptoms are maculae over the body and abnormalities in eyes, genital organs, heart and in growth. Association of hypertrophic cardiomyopathy with sudden death ...