Hypopituitarism is the deficiency of one or more pituitary hormones. It is relatively rare, with a prevalence of 45 per million and an annual incidence of about 4 per 100,000.1 It is, however, seen commonly in endocrine practice and, importantly, is associated with increased morbidity and mortality. Clinical manifestations are influenced by the etiology, severity, and rate of onset of pituitary...

Abstract Background Hypopituitarism in the elderly population is an underdiagnosed condition and may increase comorbidities related to glucose metabolism, dyslipidemia, cardiovascular risk factors. Optimization of hormone replacement that considers alterations clearance rates hormones, interaction with other medications, evaluation risk-benefit ratio treatment a big challenge for clinical pract...

BACKGROUND Extra-pituitary birth defect (EPBD) in children with congenital hypopituitarism is largely unknown. OBJECTIVE The study aims to evaluate the incidence and pattern of EPBD in children with congenital hypopituitarism and to evaluate whether it can serve as a clue to diagnose this condition. PATIENTS AND METHODS Retrospective analysis of hospital record of patients of short stature ...

Loperamide is the most commonly used antidiarrhoeal medication in the UK. We report a serious and hitherto undocumented adverse effect of chronic use in a 45-year-old man with inflammatory bowel disease. He presented to the endocrine clinic with fatigue and low libido; biochemical assessment revealed hypogonadism and adrenal insufficiency without any elevated adrenocorticotropic hormone. When s...

We read with interest the paper by Kaufman et al' on neonatal cholestasis and hypopituitarism. We have been treating a similar patient whose problems were complicated by diabetes insipidus of pituitary origin. She was referred from another hospital at the age of 1 month for assessment of secondary hypothyroidism, cholestatic jaundice, temperature instability, and microcephaly. She was born at 4...

SUMMARY A 71 - year old woman with symptomatic Rathke's Cleft cyst is reported. She had Visual disturbance, diabetes insipidus and hypopituitarism. Imaging study with computed tomography revealed the presence of suprasellar mass. After the transsphenoidal surgery and treatment with DDA VP, her symptoms showed an improvement.

conclusions radiological findings pleaded for a pituitary stone, but calcified adenomas in women, and calcified craniopharyngioma in the pediatric case could not be excluded, as our three patients were not operated on. introduction pituitary stone or pituitary calculus is a scientific enigma characterized by a large calcification in the pituitary sella. it can be discovered incidentally or in a...

Traumatic brain injury (TBI) has until recently been considered a rare cause of loss of pituitary function, accounting for less than one percent of all new cases of hypopituitarism. Newer studies have, however, indicated otherwise, and overlooking the condition in case of the life-threatening adrenal insufficiency after brain trauma may be fatal (Schneider et al., 2007a). Thus, chronic anterior...

BACKGROUND Nonfunctioning pituitary adenomas (NFPAs) are among the most common pituitary lesions and may present with hypopituitarism and/or hyperprolactinemia. OBJECTIVE To review the existing literature as it pertains to preoperative endocrine assessment in the workup for NFPAs. METHODS A systematic review methodology was utilized to identify and screen articles assessing the role and res...