cardiac involvement infrequently occurs in hypopituitarism, and lethal cardiac arrhythmias are rarely reported. we present a middle age female who died as a consequence of refractory ventricular arrhythmia whose medical history and previous laboratory investigation were consistent with hypopituitarism. we conclude that hypopituitarism may lead to electrocardiographic changes and malignant ventr...

we report a case of choroidal neovascularization (cnv) secondary to methylenetetrahydrofolate reductase (mthfr) gene mutation in a 20-year-old male patient with hypopituitarism. treatment with three consecutive injections of intravitreal ranibizumab (anti-vascular endothelial growth factor) resulted in significant improvement of the patient’s vision and the appearance of the macula. a search ...

Brief Summary: This paper describes 5 related Karelian Bear Dogs (KBDs) with a canine hypopituitarism phenotype. Genome-wide association analysis (GWAS) and next-generation sequencing revealed homozygous candidate gene defect in POU1F1. The study thus presents novel animal model for human hypopituitarism.

Dursun F, Gerenli N, Kırmızıbekmez H. Cholestasis and hypercalcemia secondary to panhypopituitarism in a newborn. Turk J Pediatr 2017; 59: 100-103. Cholestatic hepatitis and hypercalcemia are rare features of hypopituitarism in newborns. So diagnosis of hypopituitarism is frequently delayed. The most frequent symptoms of congenital hypopituitarism are hypoglycemia, prolonged jaundince and micro...

Case We report a case of post-traumatic hypopituitarism in a 9-year-old boy who was injured in a car accident. Outcome Post-traumatic hypopituitarism might be caused by moderate to severe head trauma, and while this possibility has recently drawn attention in adults, few reports are available regarding children. Our patient experienced head and facial injury, resulting in post-traumatic hypop...

OBJECTIVES The direct causes of death in Japanese patients with hypopituitarism remain unclear. In this study, the direct causes of death were investigated and compared between Japanese patients with hypopituitarism from a nation-wide autopsy database and an age- and gender-matched control population from national reports. SUBJECTS Three hundred and ninety-one subjects with hypopituitarism wh...

BACKGROUND Childhood hypopituitarism may be present at birth or may be acquired. Early diagnosis and treatment promote the best possible outcomes. METHODS The anatomy, etiologies, clinical presentation, diagnostic testing strategies, and current treatments relevant to childhood hypopituitarism are reviewed. RESULTS Children with congenital hypopituitarism may present with life-threatening h...

Panhypopituitarism occurs as a result of the insufficiency all hormones produced in anterior pituitary gland. Pituitary Stalk Interruption Syndrome (PSIS) is rare congenital syndrome leading to hypopituitarism. The should be evaluated patients with signs and symptoms hormone magnetic resonance imaging performed for etiology. Although PSIS cause hypopituitarism, it must treated replacement insuf...

sheehan’s syndrome (ss) refers to the occurrence of varying degree of hypopituitarism after parturition (1). it is a rare cause of hypopituitarism in developed countries owing to advances in obstetric care and its frequency is decreasing worldwide. however, it is still frequent in underdeveloped and developing countries. sheehan’s syndrome is often diagnosed late as it evolves slowly (2,3). rep...

Subclinical deficiency of pituitary hormones represents an intermediate situation among normal pituitary secretion and overt hypopituitarism. Clinical hypopituitarism is associated with impaired morbidity and mortality, but there are not many studies on these topics in the subclinical setting. Moreover, clinical manifestations and diagnosis criteria are not well defined, so this entity is proba...