Urticaria and angioedema are common allergic manifestations and medications are one of common triggering factors. The most severe immediate drug reaction is anaphylaxis. Apart from the well established IgE-mediated immediate type hypersensitivity reactions, the pathogenesis of drug-induced urticaria, angioedema and anaphylaxis often remains obscure. In this article, emphasis is put on nonallerg...

Exposure to ultraviolet light, especially UVB wavelengths, can impair immune responses in animals and humans. It is remarkable that this immunomodulation is not restricted to the exposed skin but is also found at other sites, i.e. systemic (distant) immunosuppression. A frequently proposed hypothesis is that UVB exposure inhibits, specifically, T helper 1 (Th1)-mediated immune responses. The ma...

BACKGROUND It is well known that atopic dermatitis (AD) is related to food hypersensitivity, although its prevalence varies among several studies according to age group, severity, country, survey time, and test method. OBJECTIVE To examine the prevalence and status of food hypersensitivity among childhood AD patients in Korea. METHODS A total of 95 patients were enrolled in the study. The h...

Multiple sclerosis is a disease with a potentially severe prognosis and epidemiologically increasing. Interferon beta 1a is a very useful maintenance therapy widely used by neurologists. In the literature, there are several case reports of  hypersensitivity reactions. In this case report we describe an anaphylactic IgE mediated reaction to interferon beta 1a. We also describe, for the first tim...

The objective of the present study was to assess the safety and tolerability of cefazolin therapy among patients with methicillin-sensitive Gram-positive bacterial infections who develop non-IgE-mediated hypersensitivity reactions (HSRs) to nafcillin. In this retrospective cohort analysis of the Outpatient Parenteral Antimicrobial Therapy program at the Massachusetts General Hospital from 2007 ...

Antiplatelet agents, which have been reviewed recently in the vista Española de Cardiologı́a, and acetylsalicylic acid in particular, e essential for the treatment of ischemic heart disease, especially the secondary prevention setting. Hypersensitivity reactions acetylsalicylic acid, whether allergic (IgE-mediated) or eudoallergic (caused by a nonimmunologic mechanism) should t be considered as ...

Background Drug hypersensitivity reactions (DHRs) can be classified into IgE-induced, immediate type and T-cell mediated, delayed-type reactions. While the former are considered as Th2-driven immune responses characterized by IL-5secretion, the later are regarded as mainly provoked by IFN-gamma-producing Th1 cells. However, it has been suggested that delayed-type DHRs could also be elicited by ...

The pathogenesis of periapical lesions has not been fully elucidated. Currently, the possibility of its being an immunologic phenomenon is receiving much attention. This article presents a review of the literature concerning immunologic reactions which may involve periapical lesions. It appears that antigen-antibody complexes and IgE-mediated reactions can initiate preliminary changes in periap...