background: polymerization of resin‑modified glass‑ionomers (rmgis) is mediated through two competing mechanisms: an acid‑base reaction and a light‑dependent resin polymerization. furthermore, pre‑conditioning with acid has resulted in an increase in enamel bond strength of some rmgis. this in vitro study evaluated the effect of pre‑conditioning and/or delayed irradiation on bond strength of th...

Interferons (IFN) are cytokines which, upon binding to cell surface receptors, trigger a series of downstream biochemical events including Janus Kinase (JAK) activation, phosphorylation Signal Transducer and Activator Transcription protein (STAT), translocation pSTAT the nucleus transcriptional activation. Dysregulated IFN signalling has been linked cancer progression auto-immune diseases. Here...

the aim of this work was to see whether tamarin immunisation with recombinant vaccinia virus expressing epstein barr virus latent proteins could prime t cells which were, on activation, able to inhibit the outgrowth of epstein barr virus transformed cells in vitro. the vaccination appeared to be successful as all vaccinated tamarins developed vaccinia lesions. however, the vaccination protocol ...

Acrosome plays an integral role during fertilization and its absence in individuals with globozoospermia leads to failure of in vitro fertilization (IVF) and oocyte activation post-intracytoplasmic sperm injection (ICSI). A variety of processes, organelles and structures are involved in acrosome biogenesis including, trans-Golgi network (TGN), acroplaxome and cellular trafficking. This review a...

In the development of neuroinflammatory diseases, alterations of the blood brain barrier (BBB) represent key events. The integrity of the BBB is partially maintained by endothelia cells (ECs), since they actively limit the transmigration of immune cells. However, the factors that cause endothelial cells to develop an immune cell-permissive phenotype are poorly understood. In general, it has bee...