Marine saponins are naturally glycosides compounds which possess important biomedical properties such as anti-cancer, antioxidant and anti-inflammatory. Nevertheless, no systematic studies on the anti-inflammatory potential of brittle star saponin and its underlying mechanisms have been reported. In this study, Ophiocoma erinaceus extracted saponin was investigated for its in vitro anti-inflamm...

Objective: Colitis is an inflammatory bowel disease with unknown etiology where many factors might play a role.  Adiantum capillus-veneris mayhave beneficial effects in colitis because of its anti-inflammatory, antioxidant, wound healing and antimicrobial effects. The aim of this study was to explore the anti-inflammatory and anti-ulcerative effects of A. capillus-...

tooth pulpal nerves include sympathetic and sensory nerves that originate from trigeminal ganglion .from the terminal of these sensory nerves neuropeptides are secreted that are neuromodulators and neurotransmitters. one of them is cgrp (calcitonin gene-related protein) which has a vasodilatory effect on pulpal vessels. near abscess and moderate injuries, this neuropeptide can lead to neural fi...

periodontitis (pd) is known to be one of most prevalent worldwide chronic inflammatory diseases. there are several treatments including antibiotics for pd; however, since drug resistance is an increasing problem, new drugs particularly derived from plants with fewer side effects are required. the effects of trans-anethole on il-1 β and tnf-α level in a rat model of pd were investigated and comp...

Meta-analysis is a standard statistical method used to combine the conclusions of individual studies that are related and the results of single study alone can not answered to deal with issues. The data are summarized by one or more outcome measure estimates along with their standard errors. The multivariate model and the variations between studies are not considered in most articles. Here we d...