Sayed-Ebrahim Sajjadi

[ 1 ] - Antiulcer effects of Zataria multiflora Boiss. on indomethacin-induced gastric ulcer in rats

Objective: Zataria multiflora has been reported to have several medicinal properties including antioxidant, antibacterial, antispasmodic, and expectorant activities. This study aimed to investigate the effect of Z. multiflora hydro-alcoholic extract (ZMHE) on peptic ulcer caused by indomethacin in rats. Materials and Methods: ZMHE was prepared by maceration, condensed by rotary evaporator and ...

[ 2 ] - Effect of Coriandrum sativum hydroalcoholic extract and its essential oil on acetic acid- induced acute colitis in rats

Objective: The aim of this study was to determine the protective effects of Coriandrum sativum on acetic acid-inducedcolitis in rats. C. sativum (Coriander) has long been used in Iranian traditional medicine and its use as an anti-inflammatory agent is still common in some herbal formulations. Materials and Methods: Colitis was induced by intra-rectal administration of 2ml acetic acid 4% in fa...

[ 3 ] - Isolation and identification of secondary metabolites from the aerial parts of Stachys lavandulifolia Vahl

Stachys lavandulifolia Vahl is an herbaceous wild plant native to Iran which is traditionally used in Iranian folk medicine as a mild sedative tea for reducing anxiety and for treatment of gastrointestinal disorders. Our previous study on ethyl acetate extract of S. lavandulifolia proved anti-anxiolytic activity and so the present study was designed to determine chemical components of this biol...

[ 4 ] - Evaluation of the antimalarial effect of Ferulago angulata (Schlecht.) Boiss. extract and suberosin epoxide against Plasmodium berghei in comparison with chloroquine using in vivo test

Background: Resistance to most antimalarial drugs has encouraged the development of novel drugs. An alternative source for discovering such drugs is natural products. Some Ferulago species are used in folk medicine for their sedative, tonic and anti-parasitic effects. Besides, coumarins isolated from this genus found to have in vitro anti-leishmanicidal effect. The present study is aimed to eva...

[ 5 ] - Isolation and Identification of a New Phenylpropanoid Derivative from the Fruits of Pimpinella Haussknechtii Rech. f. & Riedl and GC-MS Analysis of the Essential Oil

The chemical composition of the essential oil of fruits of Pimpinella haussknechtiiBoiss.was studied by GC-MS. After GC-MS analysis, one unknown component (56.7%) was observed, which was not characterized in the GC-MS library. The essential oil of P.hauskenekhtii was injected to HPLC using YMC-Pak-Sil column (250 × 20 mm) with gradient system of hexane (A), and hexane: ethyl acetate, 9:1 (B) to...

[ 6 ] - Isolation and identification of secondary metabolites from the aerial parts of Stachys lavandulifolia Vahl

Stachys lavandulifolia Vahl is an herbaceous wild plant native to Iran which is traditionally used in Iranian folk medicine as a mild sedative tea for reducing anxiety and for treatment of gastrointestinal disorders. Our previous study on ethyl acetate extract of S. lavandulifolia proved anti-anxiolytic activity and so the present study was designed to determine chemical components of this biol...

[ 7 ] - Evaluation of the antimalarial effect of Ferulago angulata (Schlecht.) Boiss. extract and suberosin epoxide against Plasmodium berghei in comparison with chloroquine using in vivo test

Background: Resistance to most antimalarial drugs has encouraged the development of novel drugs. An alternative source for discovering such drugs is natural products. Some Ferulago species are used in folk medicine for their sedative, tonic and anti-parasitic effects. Besides, coumarins isolated from this genus found to have in vitro anti-leishmanicidal effect. The present study is aimed to eva...

[ 8 ] - Isolation and Identification of a New Phenylpropanoid Derivative from the Fruits of Pimpinella Haussknechtii Rech. f. & Riedl and GC-MS Analysis of the Essential Oil

The chemical composition of the essential oil of fruits of Pimpinella haussknechtiiBoiss.was studied by GC-MS. After GC-MS analysis, one unknown component (56.7%) was observed, which was not characterized in the GC-MS library. The essential oil of P.hauskenekhtii was injected to HPLC using YMC-Pak-Sil column (250 × 20 mm) with gradient system of hexane (A), and hexane: ethyl acetate, 9:1 (B) to...

[ 9 ] - ارائه فرمولاسیون مناسب موضعی از عصاره شیرین‌بیان برای درمان پسوریازیس

Introduction: Psoriasis is a dermal disease with chronic recurrent and variable clinical schematic. Its cause isn’t known and its clinical symptoms are consist of cell proliferation, dermatitis, irritation and non predicted periods of heal and recurrent. Systemic and topical steroids are old treatments of psoriasis, but recently fumaric acid derivatives and cytotoxic drugs are prescribed. Beca...

[ 10 ] - Anti-inflammatory effect of Adiantum capillus-veneris hydroalcoholic and aqueous extracts on acetic acid-induced colitis in rats

Objective: Colitis is an inflammatory bowel disease with unknown etiology where many factors might play a role. Adiantum capillus-veneris mayhave beneficial effects in colitis because of its anti-inflammatory, antioxidant, wound healing and antimicrobial effects. The aim of this study was to explore the anti-inflammatory and anti-ulcerative effects of A. capillus-...