Known genetic susceptibility loci for type 2 diabetes (T2D) explain only a small proportion of heritable T2D risk. We hypothesize that DNA methylation patterns may contribute to variation in diabetes-related risk factors, and this epigenetic variation across the genome can contribute to the missing heritability in T2D and related metabolic traits. We conducted an epigenome-wide association stud...

Healthy lifestyle includes physical activity as the basic component however, exercises with eccentricity have been associated to a higher risk of muscle injury and slower recovery. The development exercise-induced is phenomenon that results from atypical or unaccustomed activity; intensity pain extent damage steadily deteriorate over time, when exercise session contains an eccentric component, ...

background: obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases.  the aim of this study was to examine the association of insig2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in north indian subjects. methods: the variants were investigated ...

background: the goal of the present study was to report the results of two parallel works in which the incidence of fetal deaths and also congenital malformations among the progenies of the iranian chemical victims were studied. methods: the subjects were progenies of a randomly selected population from survivors of chemical attacks during iran-iraq conflict. totally 807 male cases ranged 18-85...

actins are small globular filaments functioning in cell processes like muscle contraction, and stabilized to the sarcomeric z- discs by actin binding proteins (actinins). one of the important gene coding for actin binding proteins in fast twitch fibers is alpha- actinin- 3 (actn3). in this research, we have conducted a gene profile study investigating the genotype and allele distributions of ac...

genetic basis of diffrent arrhythmias has always been an intresting subject of resesrch for scientists. here i will review in brief the most common familia arrhythmias and the new findings regarding their mode of inhetitance. this paper will mainly focus on the genetic basis of the long qt syndromes but we will also have a short review of the genetics of three other familia congenital arrhythmo...

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Obesity is described as the accumulation of excess body fat. Several health issues are caused by fat, including cancer, type 2 diabetes, and cardiovascular disease. Additionally, obesity rates among schoolchildren young adults rising globally, putting people at risk chronic diseases. Genetics, epigenetic modification, epigenomics, environmental factors influence inheritance patterns significant...

conclusions our findings indicated that mdm2 40-bp ins/del polymorphism was not associated with all in our iranian population. further studies with larger sample sizes and diverse ethnicities are required to verify our findings. background the human murine double minute 2 (mdm2), an oncoprotein, is the major negative regulator of p53. objectives the purpose of this study was to evaluate the imp...