This paper presents results from a case study in predictive maintenance at a distribution warehouse. A simulation model was built with ARENA 5.0 for integrating predictive maintenance strategies with production planning strategies, for a conveyor system. Equipment health was monitored using condition-based parameters such as temperature and vibration for mechanical and electrical components su...

The two parameter Poisson-Dirichlet Process (PDP), a generalisation of the Dirichlet Process, is increasingly being used for probabilistic modelling in discrete areas such as language technology, bioinformatics, and image analysis. There is a rich literature about the PDP and its derivative distributions such as the Chinese Restaurant Process. This article reviews some of the basic theory and t...

In this paper, the integrated planning of production and distribution for a pulp company is considered. The tactical decisions included regard transportation of raw materials from harvest areas to pulp mills; production mix and contents at pulp mills; inventory; distribution of pulp products from mills to customers and the selection of potential orders and their levels at customers. The plannin...

This paper explores the use of weighted space syntax models to contribute to the process of integrated urban planning for Jeddah as part of a major planning project in the Saudi Arabia. The Municipality of Jeddah commissioned the production of an integrated suite of planning documents. These plans coordinate Strategic, Sub-Regional, Structural and Local plans across a citywide region and aim to...

For the continuous manufacturing processes, the integrated optimization for production planning, scheduling, and dynamic optimization usually leads to profit improvement and better overall performance. The challenge is that the integrated optimization is often a large scale problem which is difficult to solve. To deal with the computational difficulty of the integrated problem, we first propose...

Despite the inter-dependent relationship between them, production scheduling and preventive maintenance planning decisions are generally analyzed and executed independently in real manufacturing systems. This practice is also found in the majority of the studies found in the relevant literature. In this paper, heuristics based on genetic algorithms are developed to solve an integrated optimizat...

One of the clinical features of cystic fibrosis (CF) is a deep inflammatory process, which is characterized by production and release of cytokines and chemokines, among which interleukin 8 (IL-8) represents one of the most important. Accordingly, there is a growing interest in developing therapies against CF to reduce the excessive inflammatory response in the airways of CF patients. Since tran...