The review discusses some consequences of the widespread partial uncoupling of the reproduction of organelle DNA from that of nuclear DNA. I propose that in certain circumstances natural selection favors intraorganismal reproductive competition between different varieties of organelle DNA, and in other circumstances selection favors competition between organelle and nuclear DNA. Evidence is mar...

We consider the influence of disorder on the nonequilibrium steady state of a minimal model for intracellular transport. In this model particles move unidirectionally according to the totally asymmetric exclusion process (TASEP) and are coupled to a bulk reservoir by Langmuir kinetics. Our discussion focuses on localized point defects acting as a bottleneck for the particle transport. Combining...

Joint studies that involve biologists and physicists are becoming more frequent and have contributed to the identification and understanding of physical parameters underlying key biological processes. Here, we illustrate the main findings resulting from a 10-year collaboration between a cell biologist and an experimental physicist, both interested in the mechanisms of intracellular transport an...

well suited for predicting the effects of nonlinear interacPaul Smolen, Douglas A. Baxter, tions such as those dependent on oligomerization of and John H. Byrne* TFs, and for predicting the effects of biochemical time Department of Neurobiology and Anatomy delays, such as are required for intracellular transport W.M. Keck Center for the Neurobiology of Learning of macromolecules. Thus, for a sp...

Double immunofluorescent labeling experiments for lysosomes and either microtubules or vimentin intermediate filaments in cultured well-spread fibroblasts show a remarkable degree of superposition of the lysosomes and the microtubules. Under two different sets of conditions where the microtubules and intermediate filaments are well segregated from one another, the lysosomes remain codistributed...

The microtubule motor kinesin-1 plays central roles in intracellular transport. It has been widely assumed that many cellular cargos are moved by multiple kinesins and that cargos with more motors move faster and for longer distances; concrete evidence, however, is sparse. Here we rigorously test these notions using lipid droplets in Drosophila embryos. We first employ antibody inhibition, gene...

in this study, the biosynthesis of gold nanoparticles by penicillium chrysogenum, isolated from ahar copper mine, was investigated. the gold nanoparticles were synthesized by reducing the aqueous gold ions using the culture supernatant of the filamentous fungi. the uv–vis spectrum displayed a characteristic peak at 532 nm that is very specific for gold nanoparticles. the xrd spectrum confirmed ...

Abstract Background: Iron overload is a clinical consequence of repeated blood transfusions and causes significant organ damage, morbidity, and mortality in the absence of proper treatment. The primary targets of Iron chelators used for treating transfusional Iron overload are the prevention of Iron ingress into tissues and its intracellular scavenging. The present study was aimed at elucid...

Membrane/ protein trafficking in the secretory/ biosynthetic and endocytic pathways is mediated by vesicles. Vesicle trafficking in eukaryotes is regulated by a class of small monomeric GTPases the Rab protein family. Rab proteins represent the largest branch of the Ras superfamily GTPases, and have been concerned in a variety of intracellular vesicle trafficking and different intracellular sig...