Background: The aim of this study was to investigate the short term protective effect of oxytocin on testicular ischemia reperfusion injury immediately after detorsion in a rat model. Materials and Methods: Twenty adult rats were randomly divided into four groups: Control, Ischemia- Reperfusion (IR), Oxytocin and IR+ Oxytocin. Testicular ischemia was achieved by torsion of the left testis 720° ...

Background: The role of nitric oxide (NO) of endothelial or neuronal origins in cerebral ischemia and reperfusion injuries are far from being settled, extending from being important to not having any role at all.  Objective: To investigate the role of NO of endothelial and neuronal origins in ischemia/reperfusion injuries in focal cerebral ischemia, L-NAME, a non selective NO synthase inhibitor...

objective(s):bradykinin is a part of the kinin-kallikreinsystem which is involved in ischemia-reperfusion injury via b1 and b2 receptors.noscapine is a non-competitive antagonist of bradykinin receptors. noscapine has been reported to to be able to protect some organs against ischemia-reperfusion injury but its effect on renal ischemia-reperfusion injury (rir) in rats is unknown. therefore, the...

objective(s):to investigate the effects of local mild hypothermia on the expression of fas, fasl and mmp-3 after cerebral ischemia-reperfusion in rats. materials and methods:male wistar rats were divided into sham-operated group (sham), normothermia group (nt), and hypothermia group (ht). mcao/r model was established by longa’s method, and reperfusion was allowed after 2 hr occlusion. mild hypo...

BACKGROUND AND PURPOSE Phosphoinositide 3-kinase (PI3K)-γ is linked to inflammation and oxidative stress. This study was conducted to investigate the role of the PI3Kγ in the blood-brain barrier dysfunction and brain damage induced by focal cerebral ischemia/reperfusion. METHODS Wild-type and PI3Kγ knockout mice were subjected to middle cerebral artery occlusion (60 minutes) followed by reper...

results the i/r group showed a significant increase in pycnotic (dying) neurons and pretreatment with wc at doses of 500 mg/kg and 1000 mg/kg significantly reduced pycnotic and tunel positive neurons, in a dose dependent manner in ischemic brain cortex. conclusions our findings indicated that wc has neuroprotective effects and is able to reduce histopathological alterations and apoptosis in bra...

abstract introduction: resent studies have been shown beneficial effects of hyperoxia pretreatment against ischemia-reperfusion injury in different organs. the aim of the present study was to investigate early and late effects of normobaric hyperoxia (≥95% o2) pretreatment on ischemia-reperfusion injuries in isolated rat hearts. methods: following 60 and 180 minutes of hyperoxia, rat hearts wer...

introduction: renal ischemia reperfusion is considered to be one of the causes of acute renal failure (aki). in addition, renal ischemia is an important incident usually occurs due to renal transplantion, repair of suprarenal aneurysm, hemorrhagic shock. a recent study reported that reactive oxygen species (ros) are important mediators of aki. it seems essential to use antioxidant to decrease t...

background: ischemia reperfusion (ir) is the main pathology of torsion of testis and it is a common urologic emergency. there is some evidence that shows oxytocin (ot) plays role in ischemia reperfusion. objective: to evaluate this hypothesis that ot can decrease germ cell apoptotic index in testis under acute ischemia reperfusion in a rat model. materials and methods: 20 adult rats were random...