Systemically administered phosphorothioate antisense oligodeoxynucleotides can specifically affect the expression of their target genes, which affords an exciting new strategy for therapeutic intervention. Earlier studies point to a major role of the liver in the disposition of these oligonucleotides. The aim of the present study was to identify the cell type(s) responsible for the liver uptake...

ISIS, which abbreviates Intelligent Speech for Information Systems, is a trilingual spoken dialog system (SDS) for the financial domain. It handles two dialects of Chinese (Cantonese and Putonghua), as well as English ̈ the predominant languages in our region. The system supports spoken language queries regarding stock market information and simulated personal portfolios. Real-time information ...

We present a quantitative comparison between software features of the defacto standard X-ray spectral analysis tool, XSPEC and ISIS the Interactive Spectral Interpretation System. Our emphasis is on customized analysis, with ISIS offered as a strong example of configurable software. While noting that XSPEC has been of immense value to astronomers, and that its scientific core is moderately exte...

A high resolution channel parameter estimation algorithm has been developed by the professional group "Digital Communications" in collaboration with the company Elektrobit AG, Switzerland. It is named ISIS algorithm where the acronym ISIS stands for "Initialization and Searching Improved Space-alternating generalized expectation maximization" algorithm. In recent publications (Fleury et al., 20...

Introduction: The increase in spectral separation and signal-to-noise ratio at ultra-high field (7T and higher) strength enables the detection of a large number of low concentrated or coupled spin systems aside from the big landmark peaks NAA, creatine and choline. However, their detection is complicated by relatively short T2 relaxation times at ultra-high field strength (7T). The large spectr...

Background and aims: To evaluate the safety and efficacy of the intercellular adhesion molecule 1 (ICAM-1) antisense phosphorothioate oligonucleotide alicaforsen (ISIS 2302) in Crohn’s disease. Methods: Active (Crohn’s disease activity index (CDAI) 200–350), steroid dependent (prednisone 10–40 mg) Crohn’s patients were randomised into three treatment groups: placebo versus ISIS 2302 (2 mg/kg in...

One of the biggest obstacles for information dissemination to a user community is that many Digital Libraries (DL) or bibliographic databases use heterogeneous technologies that inhibit interoperability. The Open Archives Initiative (OAI) addresses interoperability by using a framework to facilitate the discovery of content stored in distributed archives or bibliographic databases through the u...

A time-scale invariant burst-detection algorithm for single-unit spike train is described. This burst analysis is an auto-adaptive algorithm that uses interand intra-burst intervals for identifying the burst itself. By using a self-adaptive algorithm, a burst is de$ned by the characteristic $ring patterns within and between bursts. Bursts are detected by auto-adaptive method when the inter-burs...

Numerical investigations have been made of responses of a Hodgkin-Huxley (HH) neuron to spike-train inputs whose interspike interval (ISI) is modulated by deterministic, semi-deterministic (chaotic), and stochastic signals. As deterministic one, we adopt inputs with the time-independent ISI and with time-dependent ISI modulated by sinusoidal signal. The Rössler and Lorentz models are adopted fo...