PURPOSE p27(Kip1)(p27) is a universal cyclin-dependent kinase inhibitor that inhibits cell cycle transition from G(1) to S phase and is primarily regulated at the post-transcriptional level via the ubiquitin-proteasome pathway. In vitro data suggest that p27 degradation may be accelerated by the c-Jun activation domain binding protein-1 (JAB1), originally identified as a coactivator of the gene...

1 Samuel begins with the description of a man named Elkanah ("God is possessing"), whose home town was Ramathaim-Zophim.' A brief ancestral history is provided, which initially prompts the reader to expect that Elkanah will be the hero of the narrative. As the story line develops, however, Elkanah takes a supporting role. This secondary role begins with the introduction of Elkanah's two wives. ...

It is suggested from analysis of proton spin-spin coupling constants that the tetrahydropyrazine ring of 5methyltetrahydrofolate in solution is in a half-chair conformation, with the methyl group at N-5 and the methylene group C-9 truns, and with C-6-H in an equatorial position. The chemical shifts and spin-spin coupling constants for the carbon-bound hydrogens of (+)-L-, (-)-L, (+)-L-~-‘H, 7-‘...

Scientists now know a lot about Alzheimer’s disease, and preventive therapies probably aren’t far off. But even when they become available, such therapies will almost certainly be very expensive. The only products currently being tested in large-scale Alzheimer’s prevention trials are antibodies against the Alzheimer’s-associated amyloid beta (Aβ) protein. Antibodies are large and delicate prot...

Intraoperative hemorrhage during pediatric craniofacial reconstruction and other surgical procedures can be significant and may exceed the circulating blood volume [1] mandating substantial perioperative transfusion. The intraoperative administration of antifibrinolytic agents is increasingly used to minimize blood loss and the need for transfusion [2]. Fibrin binding by tissue-type plasminogen...

The suppressor of cytokine signaling (SOCS) family of proteins has been implicated in the negative regulation of several cytokine pathways, particularly the receptor-associated tyrosine kinase/signal transducer and activator of transcription (Jak/STAT) pathways of transcriptional activation. SOCS-1 (also known as JAB and SSI-1) inhibits signaling by many cytokines. Because of the previously obs...

ADC bioanalytical strategies With the US FDA approval of Adcetris® (brentuximab vedotin) in 2011 and Kadcyla® (ado-transtuzumab emtansine) in 2013, antibody-drug conjugate (ADC) has been a hot topic in industry. Because of the complexity of an ADC, combining monoclonal antibody and small molecule toxin, its bioanalysis has seen unprecedented amount of discussion compared to other drug modalitie...

Metformin is an oral antidiabetic drug that has been used in the treatment of non-insulin-dependent diabetes, which improves glycemic control by primarily inhibiting hepatic gluconeogenesis and glucogenolysis [1]. Metformin is slowly absorbed after oral administration, about 60% of an oral dose is excreted in the urine as unchanged drug within 24 h, and about 30% of the dose is nonabsorbed and ...

This paper offers an analysis of similar and parallel developing projects creating a true philosophy by the disciples followers Origen Plotinus. Two texts permeated eulogy scholarch are analysed: Gregory Wonderworker’s The Address Thanksgiving to Life Plotinus Porphyry. was student Origen, while Porphyry attended his school long enough become familiar with doctrine, teaching methods personality...