Autologous mosaicplasty has been widely used for the treatment of focal, full-thickness, articular cartilage lesions of the knee and ankle joints. Commonly, the autografts are harvested from non-weight-bearing areas of the knee joint, leading to associated donor-site morbidity and representing a considerable disadvantage. This Technical Note presents a mosaicplasty procedure for harvesting auto...

Mechanical loading provides indispensible stimuli for growth and development of the articular cartilage and bone. Interestingly, depending on loading conditions loads applied to the joint can be beneficial as well as harmful to skeletal maintenance and remodeling. Moderate loads to the synovial joint, for instance, suppress the expression levels of matrix metallproteinases (MMPs), while loads a...

Even though operative microfracture is the most frequent method for treatment of limited knee joint cartilage lesions among adults, data about ouctome in children and adolescents are rare. We performed a retrospective chart review and telephone interview to analyze for the clinical outcome following knee joint cartilage defect microfracturing among 10 children. Mean postoperative Lysholm was 92...

Studying the morphology of the thumb carpometacarpal (CMC) joint cartilage in both health and disease is warranted by the high incidence of CMC osteoarthritis (OA), especially in older women; however, quantifying CMC cartilage variation in vivo remains challenging with current modalities. We used a subjectspecific cartilage model that is based on joint space volume computations from sequential ...

OBJECTIVE In vitro studies showed a beneficial effect of celecoxib on proteoglycan turnover and content of osteoarthritic cartilage. In the present study we evaluated whether these favourable effects of celecoxib could also be demonstrated in vivo. METHODS In 24 Beagle dogs, osteoarthritis (OA) was induced in one knee according to the groove model. The animals were divided into three groups a...

Articular cartilage covers the end of bones in joints and determines the load-bearing characteristics and mobility of joints. It has a thin, smooth, low friction surface with a remarkable resiliency to compressive forces. In general, chondrocytes occupy lacunae in the matrix, and produce cartilaginous ECM (extracellular matrix), which consists of type II collagen (13%), proteoglycans (7%), and ...

BACKGROUNDS Non-traumatic hip dislocation in children is most often observed in the course of developmental dysplasia of the hip (DDH) and infantile cerebral palsy. The risk of pain sensations from dislocated hip joint differentiates the discussed groups of patients. Will every painless hip joint in children with cerebral palsy painful in the future? METHODS Material included 34 samples of jo...

background: the sternoclavicular joint (scj) is the only synovial articulation between the upper extremity and the trunk. this joint is one of the most frequently used joints, so osteoarthritis (oa) should be very common. however, there are few studies about oa in this joint.   methods: in this study, 48 sternoclavicular joints from the left and right joints of 23 cases and two left joints from...

This work utilises advances in multi-tissue imaging, and incorporates new metrics which define in situ joint changes and individual tissue changes in osteoarthritis (OA). The aims are to (1) demonstrate a protocol for processing intact animal joints for microCT to visualise relevant joint, bone and cartilage structures for understanding OA in a preclinical rabbit model, and (2) introduce a comp...

The shoulder (glenohumeral) joint has the greatest range of motion of all human joints; as a result, it is particularly vulnerable to dislocation and injury. The ability to accurately measure dynamic in-vivo joint kinematics in 6-Degrees-of-Freedom (6-DOF) (translations and rotations) and subsequently quantify articular cartilage contact patterns of that joint has been and remains a difficult b...