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Krebs cycle disorders constitute a group of rare human diseases which present an amazing complexity considering our current knowledge on the Krebs cycle function and biogenesis. Acting as a turntable of cell metabolism, it is ubiquitously distributed in the organism and its enzyme components encoded by supposedly typical house-keeping genes. However, the investigation of patients presenting spe...

The airway smooth muscle (ASM) layer within the airway wall modulates airway diameter and distensibility. Even in the relaxed state, the ASM layer possesses finite stiffness and limits the extent of airway distension by the radial force generated by parenchymal tethers and transmural pressure. Airway stiffness has often been attributed to passive elements, such as the extracellular matrix in th...

The chemiosmotic theory is normally attributed to Peter Mitchell's formulation published in Nature in 1961. However, the essential elements of the theory were published 9 years earlier by Davies and Krebs. Why, then, was this earlier formulation overlooked? The success of Mitchell's theory is examined in comparison with those of Davies and Krebs and of Williams.

jnci.oxfordjournals.org 5. Guenther PM, Reedy J, Krebs-Smith SM. Development of the Healthy Eating Index–2005. J Am Diet Assoc. 2008;108(11):1896–1901. 6. Kennedy ET, Ohls J, Carlson S, Fleming K. The Healthy Eating Index: design and applications. J Am Diet Assoc. 1995;95(10):1103–1108. 7. Reedy J, Krebs-Smith SM, Bosire C. Evaluating the food environment: application of the Healthy Eating Inde...

Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate are transferred across plasma membranes of cells by secondary active transporters that couple the downhill movement of sodium to the concentrative uptake of substrate. Several transporters have been identified in isolated membrane vesicles and cells based on their functional properties, suggesting the existence of at ...