Poly(ethylenimine) (PEI) was used to transfect the endothelial cell line EA.hy 926, and the secreted levels of three gene products, tissue-type plasminogen activator (tPA), plasminogen activator inhibitor type 1 (PAI-1), and von Willebrand Factor (vWF), were assessed via ELISA. We found that the levels of these gene products in cell supernatants increased by factors up to 16.3 (tPA), 8.3 (PAI-1...

To investigate the fluorination influence on the photovoltaic performance of small molecular based organic solar cells (OSCs), six small molecules based on 2,1,3-benzothiadiazole (BT), and diketopyrrolopyrrole (DPP) as core and fluorinated phenyl (DFP) and triphenyl amine (TPA) as different terminal units (DFP-BT-DFP, DFP-BT-TPA, TPA-BT-TPA, DFP-DPP-DFP, DFP-DPP-TPA, and TPA-DPP-TPA) were synth...

12-0-Tetradecanoylphorbol-13-acetate (TPA) stimulates the release of free choline from intact NG10815 cells into the medium, without affecting the release of phosphocholine (Liscovitch, M., Blusztajn, J. K., Freese, A., and Wurtman, R. J. (1987) Biochem. J. 241, 81-86). To test the hypothesis that this response reflects activation of cellular phospholipase D, via protein kinase C (Ca’+/phosphol...

Background Tissue-type plasminogen activator (TPA) is the principal activator of plasminogen. Since hemostasis in the microcirculation of allografts is a well-recognized complication of transplantation, we asked (1) whether the distribution and amount of cellular TPA in biopsies of transplanted human hearts are associated with fibrin deposits in and around the microcirculation, (2) whether such...

The phosphodiesterase inhibitor 3-isobutyl-1-methylxan thine (IBMX), which enhances 12-O-tetradecanoylphorbol-13acetate (TPA)-stimulated cyclic nucleotide levels and ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) activity in mouse epidermis in vivo, was tested for its ability to modify the process of skin carcinogenesis using the initiation-promo tion (two-step) model system f...

BACKGROUND AND PURPOSE Tissue-type plasminogen activator (tPA) promotes excitotoxic and ischemic injury within the brain. These findings have implications for the use of tPA in the treatment of acute ischemic stroke. The plasminogen activator from vampire bat (Desmodus rotundus) saliva (D rotundus salivary plasminogen activator [DSPA]; desmoteplase) is an effective plasminogen activator but, in...

O f the many publications in this field, the ones discussed hereunder seem to be most relevant for clinical practice. Intravenous thrombolysis with tissue plasminogen activa-tor (tPA) is the only therapy proven to improve outcome in ischemic stroke. Studies of intravenous thrombolysis show that response to therapy is time-dependent; the sooner the patients receive tPA, the better the chance of ...

Submit Manuscript | http://medcraveonline.com Abbreviations: TS: Tapioca Starch; RS: Resistant Starch; HMT: Heat-Moisture Treatment; AM-L: Amylose-Lipid; XRD: X-Ray Diffraction; AM-AM: Amylose-Amylose; AMP-AMP: AmylopectinAmylopectin; PV: Peak Viscosity; CPV: Cold Paste Viscosity; SB: Set Back; BD: Break Down; TPA: Texture Profile Analysis; ANOVA: Analysis of Variance; DMRT: Duncan’s Multiple R...

The initiation and regulation of fibrinolysis has been studied by reconstitution of fibrinolytic activity in human plasma in vitro. Depletion of tissue plasminogen activator (tPA) antigen by immunoadsorption of human plasma with anti-tPA Ig Sepharose 4B leads to total loss of spontaneous fibrinolytic activity determined by lysis of a thrombin-induced clot. Addition of physiological concentratio...