RATIONALE Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) offer a powerful in vitro tool to investigate disease mechanisms and to perform patient-specific drug screening. To date, electrophysiological analysis of iPSC-CMs has been limited to single-cell recordings or low-resolution microelectrode array mapping of small cardiomyocyte aggregates. New methods of generating an...

congenital anomalies of coronary arteries, albeit rare, may be significant contributors to angina pectoris, hemodynamic abnormalities, and sudden cardiac death. a 47-year-old man referred to us with atypical chest pain. electrocardiography demonstrated no significant ischemic changes, but cardiac troponin i test was positive. the patient underwent coronary angiography, which revealed a single c...

hydatid disease is the most common infections worldwide, but it rarely involves multiple organs. herein, a 12-year-old boy is presented, who was admitted to children's medical center, tehran university of medical sciences, tehran, iran with symptoms of irritability, sleepless, and weak­ness of the extremities. patient's brain computed tomography (ct) scan with contrast media showed large multil...

The naked mole-rat (NMR) is a strictly subterranean rodent with a low resting metabolic rate. Nevertheless, it can greatly increase its metabolic activity to meet the high energetic demands associated with digging through compacted soils in its xeric natural habitat where food is patchily distributed. We hypothesized that the NMR heart would naturally have low basal function and exhibit a large...

BACKGROUND  Hypertensive patients with large blood pressure variability (BPV) have aggravated target organ damage. Because the aldosterone/mineralocorticoid receptor (MR) system is a possible mechanism of hypertensive organ damage, we investigated in spontaneously hypertensive rats (SHRs) whether a specific MR blocker, eplerenone, would prevent BPV-induced aggravation of hypertensive cardiac re...

The clinical case of cardiac pseudoamyloidosis associated with multiple myeloma Cardiac amyloidosis is an infiltrative cardiomyopathy resulting from extracellular deposition amyloid- a specific protein-polysaccharide complex. This demonstrates unverified amyloid-like heart lesion in the presence unexplained thickening wall undilated left ventricle and manifestations restrictive failure patient ...

Introduction: Optimum pain management immediately after surgeries can lower the possibility of pain syndrome and its following consequences. Opioids are amongst the analgesics used for postoperative pain control; however, their application can bring about several adverse effects. In this study, all the published articles regarding efficacy of Paracetamol   in post-cardiac surgery pain managemen...

A patient is described in whom a large congenital aneurysm or diverticulum of the right atrium caused repeated attacks of supraventricular arrhythmia and a strikingly reduced cardiac output. The aneurysm, which contained a large thrombus, was demonstrated by preoperative angiographic examinations. At the time of operation, regular rhythm returned at the moment the aneurysm was transsected. The ...

Hiatus hernia is a common medical condition. An elderly woman being investigated for dyspnoea of unknown aetiology had a transthoracic echocardiogram as part of her investigations. This alarmingly demonstrated a large left atrial mass. Further assessment with cardiac magnetic resonance imaging revealed a large hiatus hernia compressing the left atrium and no intra-cardiac mass. The case succinc...