نتایج جستجو برای: line chemotherapy
تعداد نتایج: 514303 فیلتر نتایج به سال:
BACKGROUND Randomized trials established topotecan and the combination of adriamycin, cyclophosphamide and vincristine (ACO) as second-line therapy options for small-cell lung cancer. We retrospectively evaluated the outcome of SCLC patients undergoing second-line chemotherapy. PATIENTS AND METHODS 92 consecutive patients with a diagnosis of SCLC between 2000 and 2010 were analyzed. RESULTS...
The efficacy of EGFR tyrosine kinase inhibitors (TKIs) varies among different EGFR mutations. Here, we directly compared the efficacy of first-line TKIs to chemotherapy for non-small cell lung cancer (NSCLC) patients with the L858R mutation. The progression-free survival (PFS) for patients receiving TKIs as first-line therapy was longer than those who received chemotherapy (hazard ratio [HR]: 0...
BACKGROUND This study was undertaken to evaluate the efficacy and safety of cetuximab-based therapy in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) in an area in which betel nut chewing is popular. METHODS Twenty-five patients were enrolled in the study from 2004 to 2008, of whom 13 received first-line cetuximab plus chemotherapy and 12 received second-line cetuximab wit...
PURPOSE To develop a tumor growth inhibition model for adult diffuse low-grade gliomas (LGG) able to describe tumor size evolution in patients treated with chemotherapy or radiotherapy. EXPERIMENTAL DESIGN Using longitudinal mean tumor diameter (MTD) data from 21 patients treated with first-line procarbazine, 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea, and vincristine (PCV) chemotherapy, we...
Abstract Objective First-line therapy for metastatic squamous cell carcinoma of the head and neck (R/M HNSCC) has been revolutionized by introduction anti-checkpoint monoclonal antibodies, which have shown a significant improvement in overall survival (OS) gaining approval first line setting. Efficacy safety first-line weekly chemotherapy, compared to 3-weeks treatment, was retrospectively eval...
The treatment of prostate cancer patients usually starts with androgen ablation and followed by chemotherapy; however, in some cases the tumor develops resistant phenotype. Combination therapy is currently regarded as a cornerstone in cancer therapy to overcome the drug resistance. Herein, we investigated the combinatory effect of Docetaxel and Trastuzumab with a novel nanomedicine, BCc1. Also,...
Pancreatic cancer is considered one of the most aggressive cancers with poor prognosis. It usually tardily diagnosed due to its atypical symptomatology, reason why mortality parallels incidence. Within last decade, treatment hasn’t improved and remains limited because excessive amount mutations involved in pathogeny. Through a retrospective study carried out during 7 years, going from 2012 2019...
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