De novo protein synthesis and transcription are necessary for the expression of long-lasting synaptic potentiation [long-term potentiation (LTP)] in hippocampal area CA1 and for the consolidation of long-term memory. The stability of LTP and its longevity require macromolecular synthesis at later stages, but a specific role for early protein synthesis has not been identified. Using electrophysi...

Sleep deprivation disrupts hippocampal function and plasticity. In particular, long-term memory consolidation is impaired by sleep deprivation, suggesting that a specific critical period exists following learning during which sleep is necessary. To elucidate the impact of sleep deprivation on long-term memory consolidation and synaptic plasticity, long-term memory was assessed when mice were sl...

In terms of the informax principle, and the input–output relationship of the integrate-and-fire (IF) model, IF neuron learning rules are developed. For supervised learning and with uniform weight of synapses (the theoretically tractable case), we show that the derived learning rule is stable and the stable state is unique. For unsupervised learning, within physiologically reasonable parameter r...

A validity test was conducted to determine how care level-based nurse-to-resident ratios compare with actual daily care times per resident in Germany. Stability across different long-term care facilities was tested. Care level-based nurse-to-resident ratios were compared with the standard minimum nurse-to-resident ratios. Levels of care are determined by classification authorities in long-term ...

Long-term care demographic and industry trends challenge provision of effective care and infection prevention. A systematic review was conducted to identify and evaluate cost estimates reported in the scientific literature of structure and processes intended to prevent infection among residents and staff of long-term care facilities (LTCFs). The small volume of publications regarding cost of in...

The need for long-term care (LTC) represents a “new social risk,” one that overlaps with and complements systems of care that pre-date such programs, complicating LTC program design. This commentary expands on Ikegami’s discussion of how these structural factors must be accommodated, as well as historical and cultural factors that influence public expectations of such a...

Long-term potentiation (LTP) is a persistent increase in synaptic transmission that is thought to contribute to a variety of adaptive processes including learning and memory. Although learning is known to undergo circannual variations, it is not known whether LTP undergoes similar changes despite the importance of LTP in learning and memory. Here we report that synapses in the CNS of the medici...

background: patellar mal tracking is responsible for pain and disability in patellofemoral pain syndrome (pfps). patellar kinesio taping may have different effects on short and long term usage. the aim of this study is to compare the effect of short term and long term patellar kinesio taping in patellar position on women with patellofemoral pain syndrome using magnetic resonance imaging (mri). ...

Background: Breastfeeding has long-term benefits, such as reducing obesity, allergies, asthma, wheezing, inflammatory bowel disease, diabetes, cardiovascular disease and effecting on brain development .This study aimed to investigate the relationship between exclusive breastfeeding and mental concentration in first and second grade primary school children. Methods: In this cross-sectional study...

objective: administration of amoxicillin and metronidazole along with scaling and root planning (srp) is an effective adjunctive therapy for chronic periodontitis. studies have shown that administration of azithromycin is also effective for treatment of chronic periodontitis. this study aimed to compare the effect of short-term and long-term azithromycin regimen with amoxicillin and metronidazo...