Regional lymph node metastases in colorectal cancer (CRC) decrease outcome. Whether nodal metastases function as a biomarker, i.e. as a sign of advanced disease, or are in fact involved in the metastatic process is unclear. We evaluated metastatic patterns of CRC according to the lymph node status of the primary tumor.A retrospective review of 1393 patients with metastatic CRC who underwent aut...

INTRODUCTION The thorax is an area in which distant metastases are frequently observed because it is located on the hematologic and lymphatic pathways (1). Various malignant neoplasms can metastasize to the lung (parenchymal or endobronchial), the hilar-mediastinal lymph nodes, pleura, pericardium, or to the chest wall. The lungs and mediastinum, especially, are the places where other malignanc...

Metastatic dissemination of tumor cells to regional lymph nodes is a common early feature of many human cancers including pancreatic adenocarcinoma. In contrast, lymph node metastasis is more variably observed in pancreatic endocrine tumors. The objective of this study was to assess the lymphatic system of human pancreatic endocrine tumors and correlate this to clinical behavior. Immunohistoche...

Abstract Serous endometrial carcinoma is characterized by its highly aggressive nature and represents about 10% of all carcinomas. It causes 80% deaths among women suffering from cancer. The aim our study was to determine the frequency, lymphatic local spread serous cancer compared with adenocarcinoma. Materials methods: This a retrospective conducted in period 4 years (from 2015 2019). One hun...

The use of elective lymph node dissection for intermediate-thickness melanoma has remained controversial. The technique of sentinel node biopsy (intraoperative lymphatic mapping and selective lymphadenectomy) has been developed in an attempt to identify patients who may benefit from an elective node dissection while sparing patients without occult metastases the morbidity of an elective lymphad...

We have developed a highly sensitive method for detecting prostate cancer cells using reverse transcriptase-polymerase chain reaction (RT-PCR) with primers specific for prostate-specific antigen gene. Forty-four lymph nodes obtained from 22 patients with prostate cancers were analyzed by RT-PCR to detect metastatic prostate cancer cells. RT-PCR could detect prostate-specific antigen mRNA in fiv...

The classical model of metastasis is that tumor cell dissemination occurs late in tumor development, after the primary tumor has grown, and that only then will tumor cells invade the local tissue, enter the blood or lymphatic vessels, and colonize new sites to cause metastases. However, evidence increasingly indicates that single tumor cells spread to distant sites much earlier than previously ...

background: despite the relative success of surgical resection followed by proton, proton/photon, or conventional radiotherapy in terms of recurrence-free survival, chordomas are still associated with a high rate of recurrence. to our knowledge there are only very few reported cases of this rare tumor detected by f-18 fdg-pet. materials and methods: in this case we show the significance of f-18...