growing usage of animals in the research projects has drawn more attention to their welfare and ethics surrounding this practice. dissemination of information about the existing ethical consideration and alternatives in animal experiments has two important functions; first, it increases the researcher's awareness of the possible methods of using animals in the experiment, and second, to ensure ...

background: heavy metals contaminated environment constitutes a serious problem for human and other organisms. moreover, metals such as cd, pb, and cr are toxic metals. therefore, the purpose of this study was to evaluation of cd, pb, and cr in the muscle of cow, calf, and sheep slaughtered in sanandaj city from iran. methods: this was a descriptive cross-sectional study in sanandaj city in nov...

Sex-lethal (Sxl) is the master switch gene for somatic sex determination in Drosophila melanogaster. In XX animals, Sxl becomes activated and imposes female development; in X(Y) animals, Sxl remains inactive and male development ensues. A switch gene for sex determination, called F, has also been identified in the housefly, Musca domestica. An active F dictates female development, while male de...

Cyclin D1 is a known oncogene and a key regulator of cell cycle progression. Amplification of the cyclin D1 gene and its overexpression have been associated with aggressive forms of human hepatocellular carcinoma (HCC). In this study, two independent lines of transgenic mice have been generated that express cyclin D1 under the control of the rat liver fatty acid binding protein promoter. This t...

Objective: Exposure to heavy metals such as lead (Pb) results in oxidative stress induction in the male reproductive system. Herbal medicine can be utilized as antioxidant agents against oxidative stress. Quercus brantii (QB) has shown antioxidant activity in previous studies. The aim of the present study was to evaluate effects of QB hydro-alcoholic extract against Pb-induced oxidative stress ...

Munich Wistar Frömter (MWF) rats develop spontaneous albuminuria that is linked to autosomal genetic loci and inherit a nephron deficit in both female and male animals, respectively. However, albuminuria and kidney damage are clearly more pronounced in males. Here we tested whether androgens and the androgen receptor influence albuminuria in male MWF. We first demonstrated in a pilot study that...

Video playbacks have been successfully applied to the study of visual communication in several groups of animals. However, this technique is controversial as video monitors are designed with the human visual system in mind. Differences between the visual capabilities of humans and other animals will lead to perceptually different interpretations of video images. We simultaneously presented male...

Tramadol is a centrally active synthetic opioid analgesic that is used extensively. There is no lot of information about the reproductive effects of the drug in both male and females. The present work conducted to outline the histopathological changes in ovaries and uterus of females and testis of male Wistar rats. Forty rats (Rattus norvegicus) weighing approximatel 150 g were used in the pres...