The main aim of the research focused on the production of hot-melt extrusion (HME) formulations with increased dissolution properties of albendazole (ABZ). Therefore, HME was applied as a continuous manufacturing technique to produce amorphous solid dispersions of the poorly water soluble drug ABZ combined with the polymer matrix polyvinylpyrrolidone PVP K12. HME formulations of ABZ-PVP K12 com...

Paracetamol is an important anti-inflammatory and analgesic drug widely used in biological disorders. One of major problems with this drugs is its low solubility thus dissolution rate in biological fluid, which results into poor bioavailability after oral administration. In this study polyvinyl pyrrolidone (PVP) is used to enhance bioavailability of paracetamol. Paracetamol and PVP are used in ...

Efavirenz is an HIV-1 specific, non-nucleoside reverse transcriptase inhibitor (NNRTI).It is an antiretroviral agent indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection, which is not soluble in water and lower absorption in gastric fluid. In order to improve the solubility and oral absorption of the drug in gastric fluid and to enhance its dissolution rate, soli...

In the context of the study of the wet creep of plasterboards, we have performed digital holographic interferometry measurements of the dissolution of gypsum of various quarries in water and in aqueous solutions of salts inhibiting dissolution, and of the dissolution of anhydrite in water. This technique is carried out in still water and permits to observe directly the reacting solid-liquid int...

Karst ecosystems are important landscape types that cover about 12% of the world's land area. The role of karst ecosystems in the global carbon cycle remains unclear, due to the lack of an appropriate method for determining the thickness of the solum, a representative sampling of the soil and data of organic carbon stocks at the ecosystem level. The karst region in southwestern China is the lar...

The dissolution kinetics of pandermite and hydroboracite, present in an Iranian borate ore, in sulfuric acid has been comparatively studied. The effect of particle size, temperature, and acid concentration on their dissolution rate was investigated. Dissolution rates of both minerals increased by reducing the particle size and by raising the temperature. Although, an increase in the acid concen...