نتایج جستجو برای: medullary thyroid carcinoma
تعداد نتایج: 461343 فیلتر نتایج به سال:
Multiple Neuroendocrine Neoplasia (MEN) gained notoriety after its initial descriptions, but cases of MEN are extremely rare, especially type 2B, characterized by a clinical presentation involving Medullary Thyroid Carcinoma (MTC), pheochromocytoma, and mutagenic alterations with focus on the RET proto-oncogene. Surgical intervention stands out as primary curative treatment, in metastatic condi...
The calcitonin/calcitonin gene-related peptide gene expresses two different mRNAs by tissue-specific alternative processing. The calcitonin mRNA is produced in thyroid C cells by splicing of the first three exons to the fourth polyadenylated exon. It encodes a protein precursor containing an amino-terminal peptide, calcitonin, and a carboxyl-terminal peptide (CCP I). Calcitonin gene-related pep...
CONTEXT Systemic chemotherapies for advanced or metastatic thyroid carcinomas have been of only limited effectiveness. For patients with differentiated or medullary carcinomas unresponsive to conventional treatments, novel therapies are needed to improve disease outcomes. EVIDENCE ACQUISITION The PubMed and Google Scholar search engines were used to identify publications and peer-reviewed mee...
Incidence of thyroid carcinoma has increased dramatically; however, simultaneous occurrence of different tumors in a single thyroid gland is rare and the embryologic or molecular explanations for such cases lack a solid basis. We report on a 67-year-old woman who underwent surgery for cytologically undetermined nodules in the bilateral thyroid glands. Postoperative pathology findings indicated ...
Sporadic Medullary Carcinoma of the Thyroid is a relatively uncommon entity and at the time of diagnosis, most already present loco-regional metastasis. Therapy should be aggressive to reduce recurrence and mortality. Follow-up period should continue lifelong and should also include calcium/pentagastrin infusion test, as well as 6-month interval diagnostic imaging.
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