TAMs constitute a large fraction of infiltrating immune cells in melanoma tissues, but their significance for clinical outcomes remains unclear. We explored diverse TAM parameters clinically relevant primary cutaneous samples, including density, location, size, and polarization marker expression; addition, because cytokine production is hallmark macrophages function, we measured CCL20, TNF, VEG...

Occupational exposure to solar ultraviolet (UV) radiation is a recognized work-related risk, as associated with the induction of long-term adverse health effects such Non-Melanoma Skin Cancers and cataracts. Recent research provided new data suggesting an increased risk specific forms malignant melanoma, i.e., Lentigo Maligna Melanoma, for outdoor workers, while relation cumulative ocular disea...

Introduction and purpose: 
 This review aims to analyze BRAF mutation significancy its influence on progression therapy methods within patients with melanoma. Material method: was mainly based articles collected in Pubmed years 2004-2018. The research done by looking through keywords as follows “braf kinase”, mutation”, “melanoma” “wemurafenib”. Results: selected studies have demonstrated ...

PURPOSE Uveal melanoma is a rare melanoma variant with no effective therapies once metastases develop. Although durable cancer regression can be achieved in metastatic cutaneous melanoma with immunotherapies that augment naturally existing antitumor T-cell responses, the role of these treatments for metastatic uveal melanoma remains unclear. We sought to define the relative immunogenicity of th...

Did you know the reason behind wearing sunscreen is more than just preventing a sunburn? Sun damage to skin over lifetime can lead most dangerous type of cancer, called melanoma. Melanoma abnormal growth pigment-producing cells skin, same types that make up moles. Though rare in young people, risk for melanoma increases with age. kids looks and acts differently it does adults, often making diag...

bebig ruthenium-106 ophthalmic plaques have been used for treatment of uveal melanoma, retinoblastoma, melanoma of the iris and other special applications for many years. the plaques consist of a thin film of 106ru, a beta emitter, encapsulated in pure silver. the present work proposes a new mathematical eye model for ophthalmic brachytherapy dosimetry. this new model includes detailed descript...

Cutaneous malignant melanoma is the fastest increasing malignancy in humans. Hepatoma-derived growth factor (HDGF) is a novel growth factor identified from human hepatoma cell line. HDGF overexpression is correlated with poor prognosis in various types of cancer including melanoma. However, the underlying mechanism of HDGF overexpression in developing melanoma remains unclear. In this study, hu...

EYA1 is a DNA repair enzyme that is induced after DNA damage and is upregulated in melanoma. However, its role in pathogenesis and therapeutic targeting of melanoma is unknown. Our objectives are (1) to study the relationship between EYA1 expression levels and melanoma patients' clinical pathologic parameters including survival; (2) to investigate its impact on cultured melanoma cells in vitro;...

background and objective: the frequency and pattern of eye neoplasms differ in various geographic areas. our aim was to determine the distribution of patient age, gender, ocular tumor origin, location and histological type in our region. materials and methods: in this cross-sectional study, all of the 384 eye globe enucleation cases carried out during a 10-year period in farabi medical center i...