The purpose of the study was to increase the dissolution and bioavailability of BCS class II drug, paliperidone by amorphization. The technique that was evaluated for preparing amorphous paliperidone (PAL) was Hot Melt Extrusion (HME). In case of hot melt extrusion process, copovidone was used essentially as a hydrophilic polymer with plasticizers like PEG (6000 and 20000), stearic acid and cet...

Abstract Petrological and geochemical features of gabbros fine-grained mafic rocks (mafic microgranular enclaves; MMEs) in the Inagawa Granite Ryoke Plutonic Complex were investigated to assess interactions between coexisting silicic magmas, petrogenetic relationships MMEs surrounding gabbros. The exhibit mingling textures that imply coexistence magmas did not undergo complete mixing, but compo...

In this investigation ‚the fracture toughness of A356 containing15%SiC composite was studied. Al/SiC composites have been considered because of their mechanical and erosion properties .Low fracture toughness in Al/SiC as compared with Aluminium alloys is one of its disadvantage. In this study at first A356 alloy was melted in a smelting electrical furnace then poured into the mould. A356-15% Si...

nowadays, nanoscale innovations in the forms of pathogen detection, active packaging, antimicrobial packaging and barrier formation are poised to elevate food packaging to new heights. antimicrobial nanocomposite ldpe films containing zno nanoparticles at different concentrations (e.g. 1%, 3%, 5%  and 3%  nano-zno pulse 10% polyethylene grafted maleic anhydride (pe-g-ma), w/w pure ldpe), were p...

the main objective of the present work was to synthesis polyamide 6 through anionic polymerization of ε-caprolactam in an internal mixer. the reaction time and the rheological properties of samples during the polymerization were studied. the samples were characterized by thermo gravimetry analysis (tga), differential scanning calorimeter (dsc) and ft-ir spectrometer. the melt flow behavior and ...

Products of voluminous pyroclastic eruptions with eruptive draw-down of several kilometers provide a snap-shot view of batholith-scale magma chambers, and quench pre-eruptive isotopic fractionations (i.e., temperatures) between minerals. We report analyses of oxygen isotope ratio in individual quartz phenocrysts and concentrates of magnetite, pyroxene, and zircon from individual pumice clasts o...

Tertiary andesitic basalts of the Sirjan area, Urmieh-Dokhtar Magmatic Arc, Iran, contain plagioclase phenocrysts enclosed in a matrix of amphibole, clinopyroxene and rare olivine crystals. Textural and compositional evidence suggests two significantly different types of plagioclase phenocrysts occur in the andesitic basalts. The most common type of plagioclase phenocrysts have zoning patterns ...

A novel mixing approach for achieving a good dispersion of multi-walled carbon nanotubes (MWCNTs) in ethylene- propylene diene monomer (EPDM) matrix has been investigated. In this approach EPDM was modified with vinyltrimethoxysilane (VTMS) during melt mixing. In addition the effect of MWCNT concentration on mechanical and rheological properties of modified EPDM has been studied. The formulated...

although the solubility of oxygen in molten aluminum alloys is said to be negligible, the fresh surface of the melt oxidizes quickly in the air and an oxide film is formed on the melt surface. oxide-metal-oxide sandwich technique is a method for the study of short-time surface oxide films. in this research, air was blown at 0.5 atmosphere into the melts of al-1mg and al-6mg alloys by means of a...