نتایج جستجو برای: mito mycin c

تعداد نتایج: 1059857  

Journal: :Physiological research 2009
J Matejíková J Kucharská M Pintérová D Pancza T Ravingerová

Ischemic preconditioning (I-PC) induced by brief episodes of ischemia and reperfusion (I/R) protects the heart against sustained I/R. Although activation of mitochondrial K(ATP) channels (mitoK(ATP)) interacting with reactive oxygen species (ROS) has been proposed as a key event in this process, their role in the antiarrhythmic effect is not clear. This study was designed: 1) to investigate the...

2014
Anitha D Jayaprakash Erica Benson Raymond Liang Jaehee Shim Luca Lambertini Mike Wigler Stuart A Aaronson Ravi Sachidanandam

Correspondence: [email protected] Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai , One Gustave L. Levy place, New York, 10029, USA Full list of author information is available at the end of the article Abstract Eukaryotic cells carry two genomes, nuclear (nDNA) and mitochondrial (mtDNA), which are ostensibly decoupled in their replication, segregation and inherita...

Journal: :Revista de Estudos Orientais 2016

Journal: :The American journal of physiology 1997
V K Mootha A E Arai R S Balaban

It is difficult to estimate the maximum in vivo aerobic ATP production rate of the intact heart independent of limitations imposed by blood flow, oxygen delivery, and maximum mechanical power. This value is critical for establishing the kinetic parameters that control oxidative phosphorylation, as well as for providing insights into the limits of myocardial performance. In this study, the maxim...

2018
Sang Jun Han Hong Seok Choi Jee In Kim Jeen-Woo Park Kwon Moo Park

Mitochondrial NADP+-dependent isocitrate dehydrogenase 2 (IDH2) is a major producer of mitochondrial NADPH, required for glutathione (GSH)-associated mitochondrial antioxidant systems including glutathione peroxidase (GPx) and glutathione reductase (GR). Here, we investigated the role of IDH2 in hepatic ischemia-reperfusion (HIR)-associated mitochondrial injury using Idh2-knockout (Idh2-/-) mic...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001
P E Light H D Kanji J E Fox R J French

The protective roles of sarcolemmal (sarc) and mitochondrial (mito) KATP channels are unclear despite their apparent importance to ischemic preconditioning. We examined these roles by monitoring intracellular calcium ([Ca]int), using fura-2 and fluo-3, in enzymatically isolated rat right ventricular myocytes. Myocyte mortality, estimated using a trypan blue assay, changed approximately in paral...

Journal: :Molecular ecology 2014
Yin Qi Bin Lu Haiyan Gao Ping Hu Jinzhong Fu

Mitochondrial genome (mito-genome) introgression among metazoans is commonplace, and several biological processes may promote such introgression. We examined two proposed processes for the mito-genome introgression between Rana chensinensis and R. kukunoris: natural hybridization and sex-biased dispersal. We sampled 477 individuals from 28 sites in the potential hybrid zone in the western Tsinl...

Journal: :Cardiovascular research 2006
Ashraf Hassouna Mahmoud Loubani Bashir M Matata Alan Fowler Nicholas B Standen Manuel Galiñanes

OBJECTIVES We have shown previously that human diabetic myocardium cannot be preconditioned. Here, we have investigated the basis of this cardioprotective deficit. METHODS Right atrial sections from four patient groups-non-diabetic, insulin-dependent diabetes mellitus (IDDM), non-insulin-dependent diabetes mellitus (NIDDM) receiving glibenclamide, and NIDDM receiving metformin-were subjected ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید