نتایج جستجو برای: mkn
تعداد نتایج: 586 فیلتر نتایج به سال:
Peritoneal carcinomatosis is present in more than 60% of gastric cancer, 40% of ovarian cancer, and 35% of colon cancer patients. It is the second most common cause of cancer-related mortality, with a median survival of 1 to 3 months. Cytoreductive surgery combined with intraperitoneal chemotherapy is the current clinical treatment, but achieving curative drug accumulation and penetration in pe...
BACKGROUND and aims: To clarify the interaction between gastric epithelial and mucosal T cells, we examined the role of cytokines released from epithelial cells in response to Helicobacter pylori water extract protein (HPWEP) in regulating T cell cyclooxygenase 2 (COX-2) expression and activation. METHODS Media from MKN-28 cells incubated with HPWEP for 48 hours were added to Jurkat T cells a...
Many new cyclized pyran systems with a potential anti-cancer activity were designed and prepared. Pyran showed high reactivity to various chemical reagents. 24 products of the prepared compounds chosen tested in (mM) as respectable anticancer factors. The findings revealed that 3b, 6b, 8 widely effective against three cancer cell lines including A-549 (lung carcinoma), HC-29 (colorectal adenoca...
PURPOSE Dopamine and cAMP-regulated phosphoprotein, Mr 32,000 (DARPP-32), is overexpressed during the gastric carcinogenesis cascade. Here, we investigated the role of DARPP-32 in promoting resistance to treatment with TRAIL. EXPERIMENTAL DESIGN In vitro cell models including stable expression and knockdown of DARPP-32 were used. The role of DARPP-32 in regulating TRAIL-dependent apoptosis wa...
Objective: To explore the changes of side population (SP) after treated with Nitidine chloride (NC) in human gastric cancer cells MKN-45 and OCUM-2MD3, and mechanism of it, specially, to find which proteins and miRs were involved in this process. Methods: MKN-45 and OCUM-2MD3 cells were treated with varying concentrations of NC for 72 hours. The changes of SP were detected by flow cytometry. Th...
The chemokine receptor CXCR4 is associated with the biological behavior of cancer, but few studies have addressed the expression and function of CXCR4 in human gastric cancer and its impact on disease prognosis. We studied the expression of CXCR4 using RT-PCR, Western blotting, flow cytometry, and confocal microscopy in five gastric cancer cell lines. We also examined cell proliferation, migrat...
We calculate the time dependent electron distribution under the assumption of continouos injection of new, relativistic particles, and assuming radiative cooling (by synchrotron and inverse Compton) and particle escape. Resulting photon spectra are calculated taking into account the time delays introduced by the different light travel times across the source. We apply these calculations to the ...
The study of short-term variability properties in AGN jets has the potential to shed light on their particle acceleration and emission mechanisms. We report results from a four-day coordinated multi-wavelength campaign highly-peaked blazar (HBL) Mkn 421 2019 January. obtained X-ray data AstroSAT, BVRI photometry with Whole Earth Blazar Telescope (WEBT), TeV FACT explore this HBL. continuum is r...
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