نتایج جستجو برای: molecular mechanisms of pharmacological action
تعداد نتایج: 21261883 فیلتر نتایج به سال:
nowadays in trade and economic issues, prediction is proposed as the most important branch of science. existence of effective variables, caused various sectors of the economic and business executives to prefer having mechanisms which can be used in their decisions. in recent years, several advances have led to various challenges in the science of forecasting. economical managers in various fi...
The gamma-aminobutyric acid (GABA) type A receptor system, the main fast-acting inhibitory neurotransmitter system in the brain, is the pharmacological target for many drugs used clinically to treat, for example, anxiety disorders and epilepsy, and to induce and maintain sedation, sleep, and anesthesia. These drugs facilitate the function of pentameric GABA(A) receptors that exhibit widespread ...
Dacarbazine is an antitumor prodrug which is used for the treatment of malignant metastatic melanoma and Hodgkin’s disease. It requires initial activation in liver through an N-demethylationreaction. The active metabolite prevents the progress of disease via alkylation of guanine bases in DNA strands. In order to investigate the importance of imidazole ring and its dynamictautomerization in ant...
conclusions the identification of the beneficial cardiovascular effects of dhea (s) and a better understanding of the involved mechanisms should be helpful to develop new strategies or pharmacologic approaches for many lethal diseases in western countries. context dehydroepiandrosterone (dhea) and its sulfate ester, dehydroepiandrosterone sulfate (dhea-s) have been considered as putative anti-a...
The family of voltage-gated sodium channels initiates action potentials in all types of excitable cells. Nine members of the voltage-gated sodium channel family have been characterized in mammals, and a 10th member has been recognized as a related protein. These distinct sodium channels have similar structural and functional properties, but they initiate action potentials in different cell type...
Purpose: To investigate the potential molecular mechanism underlying therapeutic effect of Bailing Tablet (BLT) on vitiligo. 
 Methods: The targets BLT and vitiligo-related genes were obtained from public databases. approach network pharmacology was utilized to explore mechanisms candidate targets. Molecular docking applied assess binding strength between BLT's compounds relevant Results: ...
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