OBJECTIVE To compare the efficacy of metformin plus megestrol acetate (MA) with that of MA alone for treating endometrial atypical hyperplasia (EAH). METHODS This pilot study included 16 EAH patients who met at least one metabolic syndrome (MS) criterion and received either adjunctive metformin plus MA (MET group) or MA monotherapy (MA group). Each patient in the MA group received 160 mg of M...

OBJECTIVE Mitotane is an adrenocytolytic agent used in adrenocortical carcinoma, inducing adrenal insufficiency, requiring replacement treatment. Such therapy is not easy to monitor because of mitotane interference. Salivary cortisol reflects a free fraction of plasma cortisol and may be useful in such patients. DESIGN The aim of our study was to evaluate salivary cortisol by HPLC coupled to ...

langerhans cell histiocytosis (lch) is a rare disorder described as three different entities including eosinophilic granulomaof bone, the hand-schuller-christian syndrome, and letterer-siwe disease. lch is currently classified into singlesystem lch, and multisystem lch. patients with single system lch have an excellent prognosis, and are mostlytreated with local therapy. multisystem lch is subd...

OBJECTIVE To investigate the effects of interventional therapy with norcantharidin-alginic acid/poly acid anhydride microspheres (N-MS) infusion via hepatic artery on hepatoma in rats. METHODS N-MS was prepared by emulsion-chemical crosslink technique. Eighty-nine hepatoma-bearing rats were randomly divided into five groups, which were normal saline group, norcantharidin (NCTD) group, blank m...

Enhancing myelin repair remains an important therapeutic goal in primary demyelinating diseases of the central nervous system (CNS) such as multiple sclerosis (MS). The emerging heterogeneity of pathology within MS lesions, and differential oligodendrocyte survival in particular, suggests that therapeutic strategies may need to be tailored to an individual patient's requirements. A number of th...

Paracetamol is a drug containing non opiod analgesics and non-steroidal antipyretics (AINS). This journal review aims to analyze find out the content of paracetamol (acetaminophen) can be detected in biological samples hair patient undergoing treatment therapy using gas chromatography-Mass spectrometry (GC-MS) method knowing how much influence length has on concentrations. Biological human were...

Multiple sclerosis (MS) is a chronic autoimmune disease caused by an insufficient suppression of autoreactive T lymphocytes. One reason for the lack of immunological control is the reduced responsiveness of T effector cells (Teff) for the suppressive properties of regulatory T cells (Treg), a process termed Treg resistance. Here we investigated whether the disease-modifying therapy of relapsing...

Gestalt Therapy has been growing and developing since its arrival in the 1950's. For some authors, Gestalt-therapy is involved process of receiving phenomenology Humanistic Psychology. However, specifics institutionalized aspects studies, as disciplinarization, are barely visible Mato Grosso do Sul (MS). In this scenario, research aims to describe analyze Gestalt-Therapy's disciplinarization MS...

Ocrelizumab, a novel member of disease-modifying therapies for multiple sclerosis (MS), is humanised monoclonal antibody against the CD20 molecule on surface B cells. Reports possible effects this in MS therapy have attracted lot attention since its approval 2017. The authors present 31-year-old female patient who was diagnosed with 2008, concomitant disease Type 1 diabetes (T1D). patient’s tre...