Examination of Müllerian inhibiting substance (MIS) signaling in the rat in vivo and in vitro revealed novel developmental stage- and tissue-specific events that contributed to a window of MIS responsiveness in Müllerian duct regression. The MIS type II receptor (MISRII)-expressing cells are initially present in the coelomic epithelium of both male and female urogenital ridges, and then migrate...

Background: Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility in women of reproductive age, affecting 7% of this population. Although not entirely understood, the etiology of PCOS is closely linked to obesity and abdominal adiposity that are considered to worsen the clinical presentation, particularly menstrual irregularities and hyperandrogenism. Lifestyle mo...

CONTEXT Puberty is associated with increased testicular testosterone (TT) synthesis, which is required to trigger spermatogenesis and to repress anti-Mullerian hormone (AMH) production. However, testicular gonadotropin stimulation during fetal and newborn life neither initiates spermatogenesis nor represses AMH. OBJECTIVE We postulated that a lack of androgen receptor (AR) expression in Serto...

In addition to its role in causing Müllerian duct regression, Müllerian inhibiting substance (MIS) is implicated in the regulation of steroidogenesis, breast and prostate growth, and ovarian follicle recruitment, all of which are processes controlled or influenced by the hypothalamic-pituitary-gonadal axis. Whereas the direct effect of MIS on gonadal, prostate, and breast cells is under investi...

CONTEXT The common characteristic of polycystic ovary syndrome (PCOS) is a disturbance in the selection of the dominant follicle, resulting in anovulation. In PCOS women, serum anti-Müllerian hormone (AMH) levels are elevated. Because AMH decreases FSH sensitivity in mice, the elevated AMH levels may contribute to the disturbed follicle selection in PCOS women. OBJECTIVE The objective of the ...

Patients with metastatic breast cancer (MBC) in visceral crisis require systemic chemotherapy. However, a coexisting cardiac failure that contradicts the use of chemotherapy often demands an alternative treatment. Here, we report case hormone-receptor-positive MBC cardiological comorbidities. She was treated combination treatment tablet Ribociclib (600 mg once daily for 21 days followed by 7 ga...

BACKGROUND The mini-pubertal period of almost six hours in neonatal male rats is thought to be an important stage in sexual development. OBJECTIVES The aim of this study was to investigate the effect of hormone inhibition during mini-puberty on testicular function in male rats. MATERIALS AND METHODS We measured serum testosterone (T), luteinizing hormone (LH) and follicle-stimulating hormon...

Polycystic ovary syndrome (PCOS) is a hormonal disorder characterised by presence of oligomenorrhoea, anovulation and hyperandrogenism in females. PCOS mainly observed women adolescent age to pre-partum resulting abortions. Symptoms include irregular menstrual cycles, anovulation, acne, hirsutism oligomenorrhea. The pathophysiology involves the primary ovarian abnormalities, endocrine alteratio...