We report a 74 year old lady presenting with cutaneous leukocytoclastic vasculitis. The underlying aetiology was established as chronic hepatitis C infection with associated cryoglobulinaemia. This presented clinically as recurrent cutaneous vasculitic eruptions with absence of any other clinical manifestations. In this case, antiviral treatment to eradicate hepatitis C virus (HCV) was deemed i...

Hepatitis B virus (HBV) is noncytopathic, hepatotropic and cause acute and chronic necroinflammatory liver diseases. Many chemokine and yours receptors are involved in the HBV pathogenesis, with a role at the infection capacity and the host response. Sequence analysis of a common variant revealed a G→A transition at position 801 (counting from the ATG start codon) in the 3’ untranslated region ...

The striking histological similarity between ASH and NASH strongly suggests that they are due to similar pathogenic mechanisms. We have proposed the hypothesis that both are diseases of “two hits”. In this model the first hit is the development of steatosis and the second a trigger of necroinflammation, with the role of steatosis being to increase the liver’s sensitivity to the second hit. Cand...

Nonalcoholic fatty liver disease (NAFLD) is commonly associated with obesity, type 2 diabetes and the metabolic syndrome, and is now recognized as the most common cause of chronic liver disease in Western countries [1-3]. NAFLD encompasses a histological spectrum of liver disease from hepatic steatosis to the more advanced necroinflammatory form, nonalcoholic steatohepatitis (NASH), which can t...

Extramedullary plasmacytoma is the uncommon phenomenon of a plasma cell neoplasm occurring outside of the bone marrow. Primary plasmacytoma is a rare occurrence in the gastrointestinal tract and exceptional to originate in the esophagus. We present a novel case of a 62-year-old man who presented to our emergency department with chest pain. A cardiovascular workup was negative, and an endoscopy ...

BACKGROUND AND AIMS Steatosis, a frequent histological finding in patients with chronic hepatitis C (CHC), has been suggested to influence liver fibrosis progression. The aim of the present study was to evaluate in patients with CHC and paired liver biopsies the relationship between the evolution of steatosis and that of fibrosis between the two biopsies. METHODS Ninety six patients were sele...

OBJECTIVE The purpose of this study was to compare the spectral characteristics of lipids, choline-containing compounds, and glutamine-glutamate complex assessed with (1)H-MR spectroscopy with the histologic findings in patients with chronic hepatitis C. SUBJECTS AND METHODS Nine healthy controls and 30 patients with biopsy-proven hepatitis C virus-related liver disease participated in this p...

fractions obtained from partitioning of aerial methanolic extract of euphorbia aellenii with chloroform (e2), ethyl acetate (e3), n-butanol (e4) and water (e5) were investigated in vitro for their phytotoxicity, insecticidal, anti-leishmanial, cytotoxicity, antibacterial and antifungal activities. sample e2 appeared to have significant phytotoxic activity. in the insecticidal screening study on...