Introduction: Nitroglycerin is a fast-acting drug that rapidly dilates coronary arteries and thus increases blood flow to these vessels, and increases the blood flow through the lateral vessels to low blood areas. It also reduces both end diastolic pressure and volume of the left ventricular. However, the effect of nitroglycerin on the circulation hemodynamic is not known. Caro...

Chronic obstructive pulmonary disease (COPD) is characterized by high cardiovascular risk, which further amplified during acute COPD exacerbations (AECOPD). Endothelial dysfunction has been previously suggested as one of the potential pathogenetic mechanisms. In order to study effects AECOPD on endothelial function assessed available functional methods, we performed a literature search involvin...

Thromboangitis obliterans (TAO; Buerger's disease) and atherosclerosis obliterans (ASO) are associated with endothelial dysfunction. The purpose of this study was to evaluate the role of circulating progenitor cells (CPCs) in endothelial function in patients with TAO and ASO. We measured flow-mediated vasodilation (FMD), nitroglycerine-induced vasodilation, and circulating CPCs in 30 patients w...

Nicorandil (SG75) is a potent K+-channel activator with an additional nitro moiety. In the present study we investigated the potential mechanisms (K+-channel activation and nitric oxide [NO] release) for the effects of nicorandil on isolated perfused rat hearts during total global ischemia using 31P-nuclear magnetic resonance. After a 10-min control perfusion, hearts were subjected to treatment...

Synthesis of the aortic pressure waveform by application of a transfer function to the radial pulse allows the estimation of aortic systolic blood pressure and aortic augmentation index, an index of pressure wave reflection derived from the early systolic component of the waveform. The accuracy of this approach for determining the aortic augmentation index has been questioned, however, and it m...

the effect of sublingual nitroglycerine (tng) on relieving pain in renal and ureteral colic was studied in a randomized, prospective, double blind and placebo controlled clinical trial. one hundred out-patients between 16-60 years of age from either sex who were admitted to the urology emergency center of ayatollah taleghani and ashrafi esfahani hospitals were chosen for this study. they were d...