abstract icssdom is a mathematical synthetic model that was written with fortran77 and in which used sa simulation annealing algorithm like an internal loop in basic structure of icss hydrodynamic simulation model. this model presented by mohseni movahed in 1381. this model is able assess current performance and present optimal operation considering downstream requirement of turnout in real con...

The present research work aims to demonstrate the effectiveness of the new methodology of Design of Dynamic Experiments (DoDE) in optimizing an important pharmaceutical reaction. An easily developed response surface model (RSM) is used instead of a hard to develop knowledge-driven process model. The DoDE approach allows the experimenter to introduce dynamic factors in the design, which during t...

Computational techniques are required for narrowing down the vast space of possibilities to plausible prebiotic scenarios, because precise information on the molecular composition, the dominant reaction chemistry and the conditions for that era are scarce. The exploration of large chemical reaction networks is a central aspect in this endeavour. While quantum chemical methods can accurately pre...

Genotyping of thiopurine S-methyltransferase (TPMT) is recommended for predicting the adverse drug response of thiopurines. In the current study, a novel version of allele-specific PCR (AS-PCR), termed competitive real-time fluorescent AS-PCR (CRAS-PCR) was developed to analyze the TPMT*2 genotype in ethnic Chinese. This technique simultaneously uses wild-type and mutant allele-specific scorpio...

Phenyl fatty hydroxamic acids (PFHAs) were synthesized from canola or palm oils and phenyl hydroxylamine (FHA) catalyzed by Lipozyme TL IM or RM IM. The reaction was carried out by shaking the reaction mixture at 120 rpm. The optimization was carried out by changing the reaction parameters, namely; temperature, organic solvent, amount and kind of enzyme, period of reaction and the mol ratio of ...

suspension system as one of the most important key elements of vehicle has always been considered by research centres and auto makers over the world and this issue is more important on sport cars which have special sensitive working conditions and even the smallest defect can strongly affect their performances. in this study, optimization of effective handling parameters of a sport car with thr...

Glycosylation patterns in antibodies critically determine biological and physical properties but their precise control is a significant challenge in biology and biotechnology. We describe herein the optimization of an endoglycosidase-catalyzed glycosylation of the best-selling biotherapeutic Herceptin, an anti-HER2 antibody. Precise MS analysis of the intact four-chain Ab heteromultimer reveals...

kinetic parameters of the ammonolysis reaction of dichloroethane in nonaqueous media are studied and the optimum reaction conditions are reported. a suitable reactor for running the reaction under high pressure in the range of 50 to 500 °c is designed. kinetic behaviours of the system is studied and other reaction parameters such as rate constant, kinetic order, and activation energy are determ...