نتایج جستجو برای: oral toxicity
تعداد نتایج: 363248 فیلتر نتایج به سال:
Explanation.................................................................................................... 333 Evaluation for acceptable daily intake .......................................................... 333 Biochemical aspects ................................................................................ 333 Absorption, distribution and excretion ......................................
Despite widespread usage of ionizing radiation in medical diagnosis and treatment methods, development of radio-protective agents is important in modulating normal tissue damages. The inherent toxicity of synthetic compounds and the confirmation of low toxicity of natural compound in accordance with long – term usage of medicine have led many researchers to investigate the radio-protective abil...
PURPOSE Diflomotecan (BN80915) is an E-ring modified camptothecin analogue that possesses greater lactone stability in plasma compared with other topoisomerase I inhibitors, a potential advantage for antitumor activity. As with other camptothecins, oral administration has pharmacological and clinical advantages. This Phase I study was performed to assess the feasibility of the administration of...
BACKGROUND Oral metronomic chemotherapy is a therapeutic option which is particularly attractive due to its ease of administration and low toxic burden. Its mechanism of action probably involves antiangiogenetic effect rather than a classical antiproliferative effect like standard maximally tolerated dose-based regimens. PATIENTS AND METHODS A retrospective analysis of 61 patients with advanc...
An experiment was conducted to study chlorpyrifos chronic toxicity in broilers and the protective effect of vitamin C. Oral administration of 0.8 mg/kg body weight (bw) (1/50 LD50) chlorpyrifos (Radar(®)), produced mild diarrhea and gross lesions comprised of paleness, flaccid consistency and slightly enlargement of liver. Histopathologically, chlorpyrifos produced degenerative changes in vario...
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