Cyclooxygenase-2 (COX-2) has a pivotal role in the pathogenesis of the lung cancer. It is known that COX-2 negatively regulates the activity of a number of tumor suppressors, including p53. Consequently, inhibition of COX-2 signaling is anticipated to be a promising approach to stabilize p53 functionality. In this regard, we investigated the effect of COX-2 signaling blockade on p53 and COX-2 e...

backgrounds and aims: p53 gene is regarded important in pathogenesis of different cancers. therefore, this study aimed to investigate the frequency of p53 gene codon 72 arg/pro polymorphism in women suffering from breast cancer. materials and methods: a total of 90 patients with breast cancer and 83 matched healthy control women participated in this case-control study. genomic dna was extracted...

p53 tumor suppressor gene, also known as “genome guardian” is mutated in more than half of allkind of cancers. in this study we have investigated the controls of environmental ph for p53 genemutation in point of specific sequence which is prone to mutagenesis. the most probable cancerousmutations occur as point mutations in exons 5-8 of p53 gene. the 175th codon of p53 is the thirdmost mutated ...

background: human papillomavirus (hpv) and p53 alterations are speculated to play a role in carcinogenesis. this study was carried out to find out the association of hpv and p53 with precancerous lesions of the oral cavity such as leukoplakia: the objective of this study was to find the association among human papilloma virus (hpv) 16 infections and p53 polymorphism in tobacco using the oral le...

introduction: gastric cancer remains the second most common cause of cancer-related deaths worldwide. in many malignancies like, lung and breast, multiple prognostic factors are known, such as mutations in ki-67, her-2/neu, p53. in this study, we evaluated immunohistochemical protein expression patterns of cell-cycle-regulators p53, proliferation marker ki-67, surface expression of cd44, her-2/...