Amyloid-β (Aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in Alzheimer’s disease pathology.Uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. Aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...

Proper planning of assembly lines is one of the production managers’ concerns at the tactical level so that it would be possible to use the machine capacity, reduce operating costs and deliver customer orders on time. The lack of an efficient method in balancing assembly line can create threatening problems for manufacturing organizations. The use of assembly line balancing methods cannot balan...

MOTIVATION Many de novo genome assemblers have been proposed recently. The basis for most existing methods relies on the de bruijn graph: a complex graph structure that attempts to encompass the entire genome. Such graphs can be prohibitively large, may fail to capture subtle information and is difficult to be parallelized. RESULT We present a method that eschews the traditional graph-based a...

This paper deals with the simulation and optimisation of disassembly-reconditioning-assembly system (DRAS) taken into account random machines failures repairs. The proposed is composed one disassembly machine, two parallel structures, assembly machine stocks to store used products, components finished product. In this study a complete process in supply chain considered, which allows acquire dis...

Electric field induced particle-particle interactions and assembly are of great interest due to their useful applications in micro devices. The behavior of particles becomes more complex if multiple particles interact with each other at the same time. In this paper, we present a numerical study of two dimensional DC dielectrophoresis based particle-particle interactions and assembly for multipl...