BALTIMORE – Cystic fibrosis–related diabetes differs from type 1 and 2 diabetes and requires different management. “Screening early and knowing which patients are at risk is really important,” Amanda Leonard said at a meeting on pediatric nutrition sponsored by Johns Hopkins University. Pulmonary function begins to decline several years before diagnosis of cystic fibrosis– related diabetes (CFR...

INTRODUCTION Hypertension and obesity in adults have been linked to increased EKG P-wave dispersion; the association has been shown in relation to hypertension, left ventricular hypertrophy and atrial enlargement. Though studies in children have linked P-wave dispersion to left ventricular hypertrophy, scant pediatric literature relates P-wave dispersion to hypertension and obesity. OBJECTIVE...

AIM Excipients are used to overcome the chemical, physical and microbiological challenges posed by developing formulated medicines. Both methyl and propyl paraben are commonly used in pediatric liquid formulations. There is no data on systemic exposure to parabens in neonates. The European Study of Neonatal Exposure to Excipients project has investigated this. Results & methodology: DBS samplin...

Address correspondence to: Oscar Arevalo, DDS, ScD, MBA, MS, 3601 NW 107th Ave. Doral, FL 33178. Email: [email protected] Objective: To determine the levels of satisfaction, license status, and desire to relocate of pediatric dentists in Puerto Rico. Methods: Pediatric dentists in Puerto Rico were surveyed via telephone interviews. Data were collected through a 34-item questionnaire that ex...

PURPOSE The effect of a chlorhexidine varnish delivery system on the levels of selected oral microorganisms was evaluated in caries active pediatric patients, ages 4 to 12 years old. METHODS Forty-six patients were enrolled into the study when they had multiple carious surfaces and salivary mutans streptococci (MS) levels higher than 10(4) colony forming units (CFUs) per milliliter. This stud...

BACKGROUND We investigated diastolic mechanical dyssynchrony and its relation to clinical status in pediatric dilated cardiomyopathy (DCM). METHODS AND RESULTS We calculated a diastolic and systolic dyssynchrony index (standard deviation of time to peak tissue early diastolic/systolic velocity in 12 left ventricular segments) in 33 children with DCM and 46 control subjects. A threshold to dia...

BACKGROUND Intrathecal IgM synthesis is reported to be associated with a worse prognosis in adults with multiple sclerosis (MS). OBJECTIVE To study the predictive value of intrathecal IgM synthesis for the clinical course of pediatric MS. METHODS Seventy children with onset of MS before the age of 16 years and followed for a median period of 10.4 years (range: 0.4-22.8 years) were studied. ...

Multiple sclerosis (MS) in children and adolescents is increasingly recognized worldwide. Demyelinating disorders of the central nervous system may overlap considerably in their clinical presentation and radiological appearance. Therefore an exact categorization might be challenging and might not be readily attainable. Rigorous radiological and laboratory investigations and longitudinal follow ...

BACKGROUND Cardiac memory refers to a change in ventricular repolarization induced by and persisting for minutes to months after cessation of a period of altered ventricular activation (eg, resulting from pacing or preexcitation in patients with Wolff-Parkinson-White syndrome). ECG imaging (ECGI) is a novel imaging modality for noninvasive electroanatomic mapping of epicardial activation and re...

None of the approved immunomodulatory drugs in adults Multiple Sclerosis (MS) patients have been officially approved for the pediatric patients and are currently used off-label in this population. In this study, we evaluated the effectiveness and tolerability of intramuscular interferon beta1-a (Avonex(®)) and subcutaneously injected interferon beta1-b (Betaferon(®)) in children with definite r...