how to cite this article: najafi mr, najafi ma, nasr z. diagnosis and management of multiple sclerosis in children. iran j child neurol. summer 2016; 10(3): 13-23. abstract growing evidence indicates the safety and well toleration of treatment by disease-modifying in children suffering multiple sclerosis (ms). the treatment is not straight forward in a great number of patients, thus patients wi...

Nádia Lunardi; Gustavo Hauber Gameiro; Maria Beatriz Borges de Araújo Magnani; Darcy Flávio Nouer; Vânia Célia Vieira de Siqueira; Simonides Consani; João Sarmento Pereira-Neto DDS, MS, Private Practice DDS, MS, PhD student, Department of Pediatric Dentistry, Orthodontics Division DDS, MS, PhD, Assistant Professor, Department of Pediatric Dentistry, Orthodontics Division DDS, MS, PhD, Professor...

CONTEXT Infection with common viruses, particularly Epstein-Barr virus (EBV), has been postulated to contribute to the pathobiology of multiple sclerosis (MS). Detailed virological studies in pediatric MS have not been previously reported. OBJECTIVE To evaluate whether children with MS are more likely to be seropositive for EBV or other common viruses than their healthy age-matched peers. D...

and Pediatric Dentistry, State University of Londrina (UEL), Brazil 2DDS, PhD, Assistant Professor, Department of Oral Medicine and Pediatric Dentistry, State University of Londrina (UEL), Brazil 3DDS, MS, PhD, Professor, Department of Pediatric and Social Dentistry, São Paulo State University (UNESP), Brazil 4DDS, MS, PhD, Professor, Department of Oral Medicine and Pediatric Dentistry, State U...

Pediatric-onset multiple sclerosis (MS) comprises approximately 3%-5% of cases of MS in North America. Recent years have seen significant advances in the diagnosis and treatment of this condition, including the introduction of proposed diagnostic criteria for pediatric demyelinating disorders, and a growing body of knowledge regarding treatment options. This article reviews current approaches t...

BACKGROUND AND PURPOSE Chronic cerebrospinal venous insufficiency is a postulated etiologic factor for multiple sclerosis, but the higher frequency with longer disease duration and progressive disability suggests that chronic cerebrospinal venous insufficiency is secondary to chronic disease. We evaluated the presence of chronic cerebrospinal venous insufficiency in pediatric-onset MS. MATERI...

BACKGROUND Pediatric-onset multiple sclerosis (POMS) prevalence and incidence rates are increasing globally. No disease-modifying therapy are approved for MS pediatric population. Hence, we aim to review the literature on POMS to guide treating physicians on the current understanding of diagnosis and management of pediatric MS. METHODS The authors performed a literature search and reviewed th...

In light of the published 2012 International Pediatric Multiple Sclerosis Group definitions for pediatric multiple sclerosis (MS) and related disorders and given that pediatric-onset MS is now formally included in the 2010 McDonald criteria for MS, we sought to review these criteria and summarize their application in children with acquired CNS demyelination. In addition, proposals are made for ...