The treatment of pain before it initiates may prevent the persistent pain-induced changes in the central nervous system that amplify pain long after the initial stimulus. The effects of pre- or postoperative intraperitoneal administration of morphine (2 to 8 mg/kg), dipyrone (40 and 80 mg/kg), diclofenac (2 to 8 mg/kg), ketoprofen (10 and 20 mg/kg), and tenoxicam (10 and 20 mg/kg) were studied ...

The aim of this study was to develop a pH responsive enteric coated extended release multiparticulate dosage form containing a model drug ketoprofen, a nonsteroidal anti-inflammatory drug used for rheumatoid arthritis. The drug loaded pellets in matrix form were prepared by using extrusion/spheronization method. The optimized pelletization method revealed that extrusion using 1 mm sieve plate a...

Urinary colics from calculosis are frequent and intense forms of pain whose current pharmacological treatment remains unsatisfactory. New and more effective drugs are needed to control symptoms and improve stone expulsion. Recent evidence suggested that the Nitric Oxide (NO) / cyclic guanosine monophosphate (cGMP)/phosphodiesterase type 5 (PDE5) system may contribute to ureteral motility influe...

BACKGROUND AND OBJECTIVES A review of all the adjuncts for intravenous regional anaesthesia concluded that there is good evidence to recommend NonSteroidal Anti-Inflammatory agents and pethidine in the dose of 30mg dose as adjuncts to intravenous regional anaesthesia. But there are no studies to compare pethidine of 30mg dose to any of the NonSteroidal Anti-Inflammatory agents. METHODS In a p...

The purpose of the study Our study was centred on the comparative research of enzymatic and non-enzymatic oxidative status mediators in the crevicular fluid on chronic and aggressive periodontitis patients, compared to periodontal healthy subjects. Materials and methods The study was conducted on 42 patients. They were divided in 3 study groups: chronic periodontitis subjects, aggressive period...

Artificial insemination (AI) involving the placing of frozen-thawed semen directly into the jenny uterine body is associated with very low pregnancy rates. This might be because of an exacerbation of the acute response of the endometrium to sperm, as seen in mares with persistent induced mating endometritis. Pregnancy rates can be increased in such mares, however, by including anti-inflammatory...

background: c-reactive protein (crp) is an acute phase reactant and has been proved to be a significant predictor of future cardiovascular events. recent studies have demonstrated a correlation between periodontitis and elevated crp levels. however, comparison between the levels of crp in two main forms of periodontitis is ambiguous. this study aims at determining and comparing the relative lev...

Introduction and objectives: positive correlation have been seen between high salivary calcium content and periodontal disease. This study was designed to compare inorganic salivary calcium, phosphate, flow rate and ph, of paraffin wax stimulated saliva of patients with gingivitis; mild periodontitis; moderate periodontitis; severe periodontitis. Methods: the present study consisted of 125 pati...