Objective To provide a contemporary and comprehensive overview of the hard soft tissue biological structures surrounding an osseointegrated dental implant (peri-implant referred to as peri-implant phenotype), in context esthetic complications. Overview The individual components phenotype (keratinized mucosa width, mucosal thickness, supracrestal height, buccal bone) have been linked different a...

Cardiomyopathies constitute a heterogeneous group of diseases with varying etiologies and clinical presentation. Advances in genetic testing have made it possible to establish genotype-phenotype relationships, determine prognosis, choose specific treatments the pediatric population. Therefore, objective this review is assist reasoning underscore importance etiological diagnosis different diseas...

Pulmonary hypertension is a convergent phenotype that presents late in the natural history of condition. The current clinical classification patients lacks granularity, and this impacts on development deployment treatment. Deep molecular phenotyping using platform ‘omic’ technologies beginning to reveal genetic architecture underlies phenotype, promising better targeting with new treatments. fu...