MUCH has been written relative to the physiologic abnormalities produced by mitral stenosis and insufficiency. Most of the data and the concepts derived therefrom have been obtained by right heart catheterization.'--8 The introduction of left heart and combined heart catheterization9-19 has greatly enhanced the value of physiologic study in patients with rheumatic mitral valve disease and has p...

Multiple interacting mechanisms control the formation and dissolution of clots to maintain blood in a state of delicate balance. In addition to a myriad of biochemical reactions, rheological factors also play a crucial role in modulating the response of blood to external stimuli. To date, a comprehensive model for clot formation and dissolution, that takes into account the biochemical, medical ...

A hemodynamic model has been developed for the patient with tetralogy of Fallot based on electrical circuit analog and oxygen balance equations. A computer program has been written for the model in the Fortran IV computer language. With the computer model it has been possible to simulate the physiologic conditions during exercise, squatting and hypoxic episodes in tetralogy of Fallot. In additi...

The ability to visualize intracranial dynamics during simulated clinical scenarios is a valuable tool for teaching brain physiology and the consequences of different medical interventions on the brain. Studies have isolated physiologic variables and shown their effects on brain dynamics. However, no studies have shown the combined effects of these variables on intracranial dynamics. This brain ...

The innovative ventricular assist systems (IVAS) is the next generation ventricular assist device for use as a permanent implantable device. Its practical application depends upon control of the electric motor and interactions of the electric motor, blood pump, and circulatory system. Computer modeling and simulation are necessary to investigate and evaluate the interactions and feasibility of ...