BACKGROUND Prescribing is a core activity for general practitioners, yet significant variation in the quality of prescribing has been reported. This suggests there may be room for improvement in the application of the current best research evidence. There has been substantial investment in technologies and interventions to address this issue, but effect sizes so far have been small to moderate....

OBJECTIVE We reported previously the results of a 6-month controlled trial in which the use of a commercially available electronic prescribing system with integrated clinical decision support and evidence-based message capability was associated with significantly lower primary care drug costs. The original study focused on new prescriptions, defined as claims for a medication that the patient h...

Adverse drug events plague the outcomes of health care services. In this research, we propose a clinical learning model that incorporates the use of a decision support system (DSS) in drug prescriptions to improve physicians’ decisions about the initial drug selection and administration. The model allows for both the analytical investigation of the effects of different DSS features on clinical ...

CONTEXT Prescribing practices for otitis media are not consistent with current evidence-based recommendations. OBJECTIVE To determine whether point-of-care evidence delivery regarding the use and duration of antibiotics for otitis media decreases the duration of therapy from 10 days and decreases the frequency of prescriptions written. DESIGN Randomized, controlled trial. SETTING Primary ...

These highlights do not include all the information needed to use SEROQUEL safely and effectively. See full prescribing information for SEROQUEL. SEROQUEL (quetiapine fumarate) tablets, for oral use Initial U.S. Approval: 1997 WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS; and SUICIDAL THOUGHTS AND BEHAVIORS See full prescribing information for complete boxed ...

Antiepileptic drugs (AEDs) including LYRICA increase the risk of suicidal thoughts or behavior in patients taking AEDs for any indication. Monitor patients treated with any AED for any indication for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior. Pooled analysis showed clinical trial patients taking an AED had approximate...

These highlights do not include all the information needed to use SEROQUEL XR safely and effectively. See full prescribing information for SEROQUEL XR. SEROQUEL XR® (quetiapine fumarate) extended-release tablets, for oral use Initial U.S. Approval: 1997 WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS; and SUICIDAL THOUGHTS AND BEHAVIORS See full prescribing info...

OBJECTIVES To identify and assess the effects of general practitioner and patient characteristics on global adherence to pharmacotherapeutic guidelines. METHODS In a cross-sectional study in the northern Netherlands, a two-level multilevel model was applied to patients (n = 269,067) in 190 practices with a total of 251 general practitioners. The dependent variable was the global adherence to ...