background: endometrial development has an important role in blastocyst adhesion and implantation. during ivf cycles, endometrial development is enhanced by progesterone. objective: the aim of this study was to compare ultrastructural and morphometrical characteristics of mice uterine endometrium in natural cycle with those in superovulated cycles received progesterone or sildenafil. materials ...

background: diazinon is a widely used organophosphate insecticide which is applied against plant pests. this compound has various side effects because it acts as an acetyl cholinesterase enzyme inhibitor. objective: the aim of present study was to investigate the effects of diazinon on pituitary–gonad axis and ovarian histological changes in rats. materials and methods: in total 50 female wista...

traumatic brain injury (tbi) is one of the most common neurological diseases with no definite treatment. erythropoietin (epo) and progesterone (prog) have been shown to have neuroprotective effects in different types of experimental brain injury models. this study was designed to determine the effect of epo, prog and combination of epo/prog on neurological outcome after traumatic brain injury. ...

abstract reactive oxygen species and oxidative stress impair β-cell function and reduce insulin secretion. it has been shown that progesterone and cilostazol possess antioxidant properties. the present study was aimed to investigate in vitro pretreatment effect of progesterone and cilostazol on insulin secretion as well as their protective effects against hydrogen peroxide-induced oxidative str...

Background: Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation and hyperandro genism and affects approximately 5-10% of women of reproductive age. In vitro maturation (IVM) of mammalian oocytes has become an efficient method to produce mature oocytes in order to use in assisted reproductive techniques such as in vitro fertilization (IVF), intra cytoplasmic sperm injection ...

spinal cord injury (sci) as a destructive crash result in neurons degeneration. the sci lead to the onset of biochemical and molecular cascades such as inflammation that in turn has a key role in neurodegeneration development. the previous studies demonstrated the role of tnf-α and inos genes in intensifying the process after sci. as a consequence, these genes overexpression intensify the infla...

background: breast cancer is the most common cancer in women, containing approximately one third of all illnesses in women. assessment of molecular markers is valuable in predicting the outcome of disease and decision making for optimal treatment. the purpose of this study was to determine the relationship between estrogen and progesterone receptors with her-2, ki67, p53, and clinicopathologica...

background: preterm birth is the major cause of neonatal mortality and morbidity. objective: the aim of this study was to evaluate the effect of prophylactic vaginal progesterone on decreasing preterm birth rate and neonatal complications in a high-risk population. materials and methods: a randomized, double-blind, placebo-controlled study was performed on 100 high-risk singleton pregnancies. v...

Abstract Background: Autoimmune progesterone dermatitis (APD) is a rare skin condition caused by sensitivity to high levels of secreted during the luteal phase menstrual cycle. This may be due various pathophysiological mechanisms including Type I and IV hypersensitivity reaction, potential cross-reactivity with other endogenous steroid hormones such as 17-α-hydroxyprogesterone. We present case...

Progesterone withdrawal is essential for parturition, but the mechanism of this pivotal hormonal change is unclear in women and other mammals that give birth without a pre-labor drop in maternal progesterone levels. One possibility suggested by uterine tissue analyses and cell culture models is that progesterone receptor levels change at term decreasing the progesterone responsiveness of the my...