Precision (target) medicine is proposed as a new strategy to identify and develop highly selective drugs against specific targets for the disease more precise tailoring of medicines target populations patients. can be an important approach create novel safer therapeutics (tyrosine kinase inhibitors, tumour monoclonal antibodies) patients with gene mutation, aberrations, or protein over-expressi...

The effect of various phospholipase A2 and protein kinase inhibitors on the arachidonic acid liberation in bovine platelets induced by the protein kinase activator 12-O-tetradecanoylphorbol-13-acetate (TPA) was studied. TPA stimulates arachidonic acid release mainly by activating group IV cytosolic PLA2 (cPLA2), since inhibitors of this enzyme markedly inhibited arachidonic acid formation. Howe...

Objective(s): The rotavirus nonstructural protein 4 (NSP4) is responsible for the increase in cytoplasmic calcium concentration through a phospholipase C-dependent and phospholipase C-independent pathways in infected cells. It is shown that increasing of intracellular calcium concentration in rotavirus infected cells is associated with the activation of some members of protein kinases family su...

Introduction . Current chemotherapy of breast cancer has a wide range disadvantages, in particular, the development therapy-related infections and hormonal imbalance. Combination main cytostatic with glucocorticoids allows to broaden its therapeutic interval decrease total toxicity treatment. However, long-term treatment leads severe side effects via activation multiple molecular mechanisms. Th...

objective(s): the rotavirus nonstructural protein 4 (nsp4) is responsible for the increase in cytoplasmic calcium concentration through a phospholipase c-dependent and phospholipase c-independent pathways in infected cells. it is shown that increasing of intracellular calcium concentration in rotavirus infected cells is associated with the activation of some members of protein kinases family su...