نتایج جستجو برای: protein phosphatases
تعداد نتایج: 1237089 فیلتر نتایج به سال:
Glomerular podocytes are critical for the barrier function of the glomerulus in the kidney and their dysfunction causes protein leakage into the urine (proteinuria). Nephrin is a key podocyte protein, which regulates the actin cytoskeleton via tyrosine phosphorylation of its cytoplasmic domain. Here we report that two protein tyrosine phosphatases, PTP1B and PTP-PEST negatively regulate nephrin...
Tens of thousands protein-protein interactions (PPIs) have been found in human cells and many these macromolecular partnerships could determine the cell growth death. Thus there is a need to develop methods catalogue macromolecules by detecting their interactions, modifications, cellular locations. It will be helpful for scientists compare difference between diseased state its normal find poten...
The Hippo pathway regulates organ size and tissue homeostasis in response to multiple stimuli, including cell density and mechanotransduction. Pharmacological inhibition of phosphatases can also stimulate Hippo signaling in cell culture. We defined the Hippo protein-protein interaction network with and without inhibition of serine and threonine phosphatases by okadaic acid. We identified 749 pr...
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