it is now well established that the type la of serine/threonine protein phosphatases (pp1α) may be implicated in malignant phenotype. although the pp1α mrna level increased in livers at preneo-plastic stages of hepatocarinogenesis and all of examined rat ascites hepatomas, unexpectedly, dra-matically decreased in some of primary hepatomas. in order to elucidate the low level of pp1α mrna in som...

Platelets are small enucleated cell fragments specialized in the control of hemostasis, but also playing a role angiogenesis, inflammation and immunity. This plasticity demands broad range physiological processes. Platelet functions mediated through variety receptors, concerted action which must be tightly regulated, order to allow specific timely responses different stimuli. Protein phosphoryl...

Protein phosphorylation and dephosphorylation are two essential vital cellular mechanisms that regulate many receptors enzymes through kinases phosphatases. Ca2+- dependent phosphatases responsible for controlling neuronal processing; balance is achieved opposition. During molecular of learning memory, generally modulate positively while negatively. This review outlines some the critical physio...

Abstract Receptor‐type protein tyrosine phosphatases (RPTPs), Class I phosphatases, are involved in human tumor cell proliferation, apoptosis, migration, and invasion through reversible phosphorylation of residues. This review summarizes the expression role RPTPs cancer illustrates signaling pathway mechanisms effecting oncogenesis, progression, prognosis, angiogenesis, so as to provide more ef...